Enterovirus detection in different regions of Madagascar reveals a higher abundance of enteroviruses of species C in areas where several outbreaks of vaccine-derived polioviruses occurred

Richter Razafindratsimandresy, Marie-Line Joffret, Soa Fy Andriamandimby, Seta Andriamamonjy, Sendraharimanana Rabemanantsoa, Vincent Richard, Francis Delpeyroux, Jean-Michel Heraud & Maël Bessaud
Abstract Background Poliomyelitis outbreaks due to pathogenic vaccine-derived polioviruses (VDPVs) are threatening and complicating the global polio eradication initiative. Most of these VDPVs are genetic recombinants with non-polio enteroviruses (NPEVs) of species C. Little is known about factors favoring this genetic macroevolution process. Since 2001, Madagascar has experienced several outbreaks of poliomyelitis due to VDPVs, and most of VDPVs were isolated in the south of the island. The current study explored some of the viral...
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