A review on the application of the exposome paradigm to unveil the environmental determinants of age-related diseases

Enmin Ding, Yu Wang, Juan Liu, Song Tang & Xiaoming Shi
Abstract Age-related diseases account for almost half of all diseases among adults worldwide, and their incidence is substantially affected by the exposome, which is the sum of all exogenous and endogenous environmental exposures and the human body’s response to these exposures throughout the entire lifespan. Herein, we perform a comprehensive review of the epidemiological literature to determine the key elements of the exposome that affect the development of age-related diseases and the roles of aging...
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