The link between intrauterine adhesions and impaired reproductive performance: a systematic review of the literature

Angelo B. Hooker, Robert A. de Leeuw, Mark Hans Emanuel, Velja Mijatovic, Hans A. M. Brolmann & Judith A.F. Huirne
Abstract Background Intrauterine adhesions (IUAs) are one of the main reproductive system diseases in women worldwide. Fusion between the injured opposing walls leads to partial-to-complete obliteration of the cavity and/or cervical canal. The main clinical manifestations in case of IUAs are menstrual disturbances, cyclic pain and reproductive disorders. The reproductive outcomes of women with IUAs remain limited and inefficient compared to women without IUAs, even after adhesiolysis. An exact understanding of the underlying mechanisms and...
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