Genotyping and biofilm formation of Mycoplasma hyopneumoniae and their association with virulence

Yuzi Wu, Yanfei Yu, Lizhong Hua, Yanna Wei, Yuan Gan, Hafizah Yousuf Chenia, Yixuan Wang, Xing Xie, Jia Wang, Maojun Liu, Guoqing Shao, Qiyan Xiong & Zhixin Feng
Abstract Mycoplasma hyopneumoniae, the causative agent of swine respiratory disease, demonstrates differences in virulence. However, factors associated with this variation remain unknown. We herein evaluated the association between differences in virulence and genotypes as well as phenotype (i.e., biofilm formation ability). Strains 168 L, RM48, XLW-2, and J show low virulence and strains 232, 7448, 7422, 168, NJ, and LH show high virulence, as determined through animal challenge experiments, complemented with in vitro tracheal mucosa...
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