SLIT2 promoter hypermethylation predicts disease progression in chronic myeloid leukemia

De-long Wu, Yun Wang, Ting-juan Zhang, Ming-qiang Chu, Zi-jun Xu, Qian Yuan, Ji-chun Ma, Jiang Lin, Jun Qian & Jing-dong Zhou
Abstract Background Aberrant DNA methylation plays a crucial role in the progression of myeloid neoplasms. Previously, our literature reported that slit guidance ligand 2 (SLIT2) promoter methylation was associated with disease progression and indicated a poor prognosis in patients with myelodysplastic syndrome. Herein, we further investigated the clinical implications and role of SLIT2 promoter methylation in patients with chronic myeloid leukemia (CML). Methods The level of SLIT2 promoter methylation was determined in 104 CML patients,...
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