Biomarkers for isolated congenital heart disease based on maternal amniotic fluid metabolomics analysis

Xuelian Yuan, Lu Li, Hong Kang, Meixian Wang, Jing Zeng, Yanfang Lei, Nana Li, Ping Yu, Xiaohong Li & Zhen Liu
Abstract Introduction Congenital heart disease (CHD) is one of the most prevalent birth defects in the world. The pathogenesis of CHD is complex and unclear. With the development of metabolomics technology, variations in metabolites may provide new clues about the causes of CHD and may serve as a biomarker during pregnancy. Methods Sixty-five amniotic fluid samples (28 cases and 37 controls) during the second and third trimesters were utilized in this study. The metabolomics of...
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