Water extract from artichoke ameliorates high-fat diet-induced non-alcoholic fatty liver disease in rats

Aihua Deng, Fengying Liu, Xuchong Tang, Yun Wang, Peng Xie, Qifu Yang & Bing Xiao
Abstract Background The “multiple-hit” hypothesis is currently the most widely accepted theory for non-alcoholic fatty liver disease (NAFLD) pathogenesis. The present study aimed to investigate the effects of the water extract of artichoke (WEA) on NAFLD and its underlying mechanism. Methods Rats were fed a high-fat diet (HFD) for 8 weeks to induce NAFLD and then treated with WEA at three doses (0.4, 0.8, and 1.6 g/kg body weight, BW) for 8 weeks. At the...
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