An investigation of codon usage pattern analysis in pancreatitis associated genes

Yuanyang Li, Rekha Khandia, Marios Papadakis, Athanasios Alexiou, Alexander Nikolaevich Simonov & Azmat Ali Khan
Abstract Background Pancreatitis is an inflammatory disorder resulting from the autoactivation of trypsinogen in the pancreas. The genetic basis of the disease is an old phenomenon, and evidence is accumulating for the involvement of synonymous/non-synonymous codon variants in disease initiation and progression. Results The present study envisaged a panel of 26 genes involved in pancreatitis for their codon choices, compositional analysis, relative dinucleotide frequency, nucleotide disproportion, protein physical properties, gene expression, codon bias, and interrelated...
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