Computation and molecular pharmacology to trace the anti-rheumatoid activity of Angelicae Pubescentis Radix

Junhao Zhang, Rui Wang, Xiao Liang, Hao Tian Bai, Ya Lan Li, Shuhui Sun, Qianqian Zhang & Jing Yang
Abstract Background The mechanism of action of Angelicae Pubescentis Radix in rheumatoid arthritis treatment is complex; the pathways and protein targets involved remain unclear. This study predicted the targets and signaling pathways of Angelicae Pubescentis Radix for rheumatoid arthritis treatment using network pharmacology and molecular docking technology and clarified its mechanism of action using in vitro cellular experiments. Methods Angelicae Pubescentis Radix active components and related targets were retrieved from the traditional Chinese medicine systems...
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