Supplementary material from \"Impact of phylogeny on structural contact inference from protein sequence data\"

Nicola Dietler, Umberto Lupo & Anne-Florence Bitbol
Local and global inference methods have been developed to infer structural contacts from multiple sequence alignments of homologous proteins. They rely on correlations in amino acid usage at contacting sites. Because homologous proteins share a common ancestry, their sequences also feature phylogenetic correlations, which can impair contact inference. We investigate this effect by generating controlled synthetic data from a minimal model where the importance of contacts and of phylogeny can be tuned. We demonstrate that...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.