Nuovi indicatori di sbilanciamento e prevedibilità nei disegni sequenziali randomizzati: confronti fra 'biased coin designs' diversi

Alessandro Baldi Antognini, Antonella Bodini & Alessandra Giovagnoli
Efron's (1971) Biased Coin Design is a well-known randomization technique of sequential clinical trials for comparing two treatments in the absence of prognostic factors that helps neutralize selection bias while keeping the experiment fairly balanced., Efron's idea has been extended to other types of procedures, but only their asymptotic properties as regards selection bias and imbalance are considered in the literature. In this paper we define new indicators of selection bias and imbalance of the...