Some recent developments in the design of adaptive clinical trials

BALDI ANTOGNINI, ALESSANDRO; Department Of Statistical Sciences-University Of Bologna, GIOVAGNOLI, ALESSANDRA; Department Of Statistical Sciences-University Of Bologna & ZAGORAIOU, MAROUSSA; Department Of Statistical Sciences-University Of Bologna
For clinical trials that compare two or more competing treatments, the literature proposes several randomization rules that aim at favouring, at each stage of the trial, the treatment that appears to be best. In two papers the present authors have suggested criteria of optimal allocation that combine inferential precision and ethical gain by means of flexible weights, in order to achieve a good trade-off between efficiency and ethical concerns. The ensuing optimal allocation of the...