Investigations on the Biosynthesis of Rishirilides

Andreas Bechthold & Chijian Zuo
3 Table of contents 1 Introduction ............................................................................................................ 12 1.1 Natural products as pharmaceutical compounds ................................................. 12 1.2 The diversity of polyketides.............................................................................. 12 1.3 Pharmaceutical active compounds of type II polyketide ...................................... 15 1.4 Type II PKS enzymes....................................................................................... 21 1.4.1 Priming enzymes ...................................................................................... 21 1.4.2 Minimal PKS enzymes.............................................................................. 22 1.4.3 Ketoreductases ......................................................................................... 22 1.4.4 Cyclases/aromatases ................................................................................. 24 1.4.5 Quinone-forming monooxygenases ............................................................ 24 1.4.6 Flavin-dependent monooxygenases ............................................................ 26 1.4.7 Oxidative rearrangement enzymes ............................................................. 28 1.4.8 Methyltransferases.................................................................................... 29...
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