Aptamers in the age of big data : development and application of algorithmic solutions in the field of high- throughput systematic evolution of ligands by exponental enrichment

Jan Hoinka
Aptamers are short, 15-150 nucleotide long RNA/DNA molecules capable of binding, with high affinity and specificity, a specific target molecule via sequence and structure features that are complementary to the biochemical characteristics of the target's surface. The spectrum of aptamer targets spans from small organic molecules, over transcription factors and other proteins or protein complexes, to the surfaces of viruses and entire cells. This broad range of targets makes aptamers suitable candidates for a variety...
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