Donor age dependent graft development and recovery in a rat model of Huntington’s disease: Histological and behavioral analysis

Stefanie Capetian
Neural cell replacement therapy using fetal striatal cells has been shown to have disease modifying capacity in clinical trials in Huntington’s disease (HD) patients, although the results have been inconsistent. One of the contributing factors to the variable outcome could be the different repair potential of the range of donor ages used. The current study investigated the proliferation and differentiation potential of different donor ages in culture as well as, based on the rodent lesion...
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