Novel reconstruction and quantification methods for Oxygen-17 magnetic resonance imaging at clinical field strengths

Dmitry Kurzhunov
Oxygen metabolism, which is altered by many neurodegenerative diseases such as Alzheimer’s disease or Parkinson’s disease and in brain tumor regions, is quantified by the cerebral metabolic rate of oxygen consumption (CMRO2). Positron emission tomography (PET) with the oxygen isotope 15O is considered the gold standard for CMRO2 mapping in humans; however, it is rarely used due to the short isotope half-life of only 2 min, which requires costly on-site production. An alternative method is...
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