Cardiovascular risk factors and accelerated cognitive decline in midlife

Kristine Yaffe, Amber L. Bahorik, Tina D. Hoang, Sarah Forrester, David R. Jacobs, Cora E. Lewis, Donald M. Lloyd-Jones, Stephen Sidney & Jared P. Reis
ObjectiveIncreasing evidence supports an association between midlife cardiovascular risk factors (CVRFs) and risk of dementia, but less is known about whether CVRFs influence cognition in midlife. We examined the relationship between CVRFs and midlife cognitive decline.MethodsIn 2,675 black and white middle-aged adults (mean age 50.2 ± 3.6 years, 57% female, 45% black), we measured CVRFs at baseline: hypertension (31%), diabetes mellitus (11%), obesity (43%), high cholesterol (9%), and current cigarette smoking (15%). We administered cognitive...
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