Association of Serum Paraoxonase/Arylesterase Activity With All-Cause Mortality in Maintenance Hemodialysis Patients

Yasunori Suematsu, Masaki Goto, Christina Park, Ane C.F. Nunes, WangHui Jing, Elani Streja, Connie M. Rhee, Siobanth Cruz, Moti L. Kashyap, Nosratola D. Vaziri, Vasanthy Narayanaswami, Kamyar Kalantar-Zadeh & Hamid Moradi
Context: In end-stage renal disease (ESRD), serum high-density lipoprotein cholesterol (HDL-C) level is not an accurate predictor of mortality, partly because it does not necessarily correlate with indices of HDL function. Paraoxonase (PON) is a major enzyme constituent of HDL and key component of HDL antioxidant activity. Apolipoprotein (Apo) A-I is the core HDL structural protein that plays a major role in various aspects of HDL function. Objective: We sought to examine PON activity and...
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