Pathway enrichments from untargeted metabolomics of plasma of Peromyscus leucopus and Mus musculus with or without LPS treatment

Alan Barbour, Nurul Islam, Ana Milovic & John Belisle
Animals that are competent reservoirs of zoonotic pathogens commonly suffer little morbidity from the infections. To investigate mechanisms of this tolerance of infection, we used single-dose lipopolysaccharide (LPS) as an experimental model of inflammation and compared the responses by two rodents: Peromyscus leucopus, white-footed deermouse and reservoir for agents of Lyme disease and other zoonoses, and the house mouse Mus musculus. Four hours after injection with LPS or saline, blood, spleen and liver samples were...
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