Genetic profiling of the isoprenoid and sterol biosynthesis pathways of Trypanosoma cruzi

Raul O Cosentino, Patricio Diosque & Fernán Agüero
Background. Sterols such as cholesterol, are important components of cellular membranes. But unlike mammalian cells, the main sterols found in the membranes of trypanosomes and fungi are ergosterol, and other 24-methyl sterols, which are required for growth and viability. In spite of this strict requirement, this group of organisms have evolved different strategies to produce and/or obtain sterols. Trypanosoma cruzi is the causative agent of Chagas Disease. In this parasite, one of the few validated...