Chemical shift-based methods in NMR structure determination

Santrupti Nerli, Andrew C. McShan & Nikolaos G. Sgourakis
Chemical shifts are highly sensitive probes that can be harnessed by NMR spectroscopists and structural biologists as conformational parameters to characterize a range of biological molecules. Traditionally, assignment of chemical shifts has been a labor-intensive process requiring numerous samples and a suite of multidimensional experiments. Over the past two decades, the development of complementary automated and computational approaches has bolstered the analysis, interpretation and utilization of chemical shifts for elucidation of high-resolution protein and nucleic...
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These counts follow the COUNTER Code of Practice, meaning that Internet robots and repeats within a certain time frame are excluded.
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