Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis - Analysis macros

Christopher M Henstridge & Tara L Spires-Jones
In addition to motor neurone degeneration, up to 50% of Amyotrophic Lateral Sclerosis (ALS) patients present with cognitive decline. Understanding the neurobiological changes underlying these cognitive deficits is critical, as cognitively impaired patients exhibit a shorter survival time from symptom onset. Given the pathogenic role of synapse loss in other neurodegenerative diseases in which cognitive decline is apparent, such as Alzheimer’s disease, we aimed to assess synaptic integrity in the ALS brain. Here we have...
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