Further evidence for the sleep-promoting effects of 5-HT2A receptor antagonists and demonstration of synergistic effects with the hypnotic, zolpidem

Guy Griebel
Hypnotic drugs are effective in treating sleep initiation difficulties. However, during their administration, slow wave sleep (SWS) and rapid eye movement (REM) sleep do not regain normal levels or can be even further suppressed. During the search for compounds that can increase SWS, the attention was directed to a particular group of drugs, namely, the 5-HT2A antagonists. 5-HT2A receptors are distributed in brain regions involved in the physiological regulation of the mammalian sleep-wake cycle, including...
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