CIViC: Crowdsourcing the Clinical Interpretation of Variants in Cancer

Malachi Griffith, Nicholas Spies, , Josh McMichael, Adam Coffman, Benjamin Ainscough, Rachel Bilski, James Eldred, David Larson, Jason Walker, Richard Wilson, Elaine Mardis &
The landscape of the genomics of tumorigenesis has been systematically surveyed in recent years, identifying thousands of potential cancer-driving alterations. However, few resources exist to facilitate prioritization and interpretation of these alterations in a clinical context. Interpreting the events from even a single case requires both extensive bioinformatics expertise as well as an understanding of cancer biology and clinical paradigms. This interpretation step now represents a significant bottleneck, preventing the realization of personalized medicine. To...
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