SOuLMuSiC: Predicting Protein Solubility Changes upon point Mutations

Raphaël Bourgeas, Fabrizio Pucci & Marianne Rooman
Many fields of science and industry depend on efficient production of active protein using heterologous expression in Escherichia coli. Thus, the prediction of protein solubility have already been widely developped in many studies mainly based on amino acid sequence (e.g. : PROSO II, SolPRO). Here, we deepened the field of protein engineering by the analysis of protein solubility changes upon point mutations (Δs). This analysis is based on a series of statistical potentials which are...
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