Probing the role(s) of rare codons in coding sequences of Escherichia coli

Athina Theodosiou & Vasilis Promponas
In this work we applied the recently developed standalone version of LaTcOm (Theodosiou and Promponas, 2012; Theodosiou and Promponas, in preparation), which offers access to different algorithmic approaches for detecting rare codon clusters (RCCs). We initially compared the algorithms implemented in LaTcOm and then RCCs were detected and analyzed for the complete E. coli protein coding sequences aiming to unravel possible roles for RCCs, combining functional and structural information.

We conclude that there is no clear...
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