Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium.

Martin Bahls, Matthias W Lorenz, Marcus Dörr, Lu Gao, Kazuo Kitagawa, Tomi-Pekka Tuomainen, Stefan Agewall, Gerald Berenson, Alberico L Catapano, Giuseppe D Norata, Michiel L Bots, Wiek Van Gilst, Folkert W Asselbergs, Frank P Brouwers, Heiko Uthoff, Dirk Sander, Holger Poppert, Michael Hecht Olsen, Jean Philippe Empana, Ulf Schminke, Damiano Baldassarre, Fabrizio Veglia, Oscar H Franco, Maryam Kavousi, Eric De Groot … & Simon G Thompson
AIMS Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. METHODS AND RESULTS An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT...
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