Impact of recruitment and retention on all-cause mortality in a large all-comers randomised controlled trial: insights from the GLOBAL LEADERS trial.

Kuniaki Takahashi, Norihiro Kogame, Mariusz Tomaniak, Ply Chichareon, Chun-Chin Chang, Rodrigo Modolo, Edouard Benit, Christoph Liebetrau, Luc Janssens, Maurizio Ferrario, Aleksander Zurakowski, Robert Jan Van Geuns, Marcello Dominici, Kurt Huber, Pawel Buszman, Leonardo Bolognese, Carlo Tumscitz, Krzysztof Żmudka, Adel Aminian, Mathias Vrolix, Ivo Petrov, Joanna J Wykrzykowska, Robbert J De Winter, Christian Hamm, Philippe Gabriel Steg … & Patrick W Serruys
OBJECTIVE Recruitment and retention in trials may bias the results and subsequently complicate their interpretation and validity. The aim of this study is to evaluate the impact of recruitment and retention on all-cause mortality in a large all-comers trial. METHODS The recruitment rate in each investigating center of the GLOBAL LEADERS trial was assessed and the 130 centers were subdivided into low and high recruiters according to the median, with all-cause mortality then compared between...
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