Pneumococcal serotype determines growth and capsule size in human cerebrospinal fluid

Annelies Müller, Anke Salmen, Susanne Aebi, Linda De Gouveia, Anne Von Gottberg & Lucy J. Hathaway
Background: The polysaccharide capsule is a major virulence factor of S. pneumoniae in diseases such as meningitis. While some capsular serotypes are more often found in invasive disease, high case fatality rates are associated with those serotypes more commonly found in asymptomatic colonization. We tested whether growth patterns and capsule size in human cerebrospinal fluid depends on serotype using a clinical isolate of S. pneumoniae and its capsule switch mutants. Results: We found that the...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.