Pathway and network analysis of more than 2500 whole cancer genomes.

Matthew A Reyna, David Haan, Marta Paczkowska, Lieven P C Verbeke, Miguel Vazquez, Abdullah Kahraman, Sergio Pulido-Tamayo, Jonathan Barenboim, Lina Wadi, Priyanka Dhingra, Raunak Shrestha, Gad Getz, Michael S Lawrence, Jakob Skou Pedersen, Mark A Rubin, David A Wheeler, Søren Brunak, Jose M G Izarzugaza, Ekta Khurana, Kathleen Marchal, Christian Von Mering, S Cenk Sahinalp, Alfonso Valencia, Rory Baldwin Johnson, Jüri Reimand … & Benjamin J Raphael
The catalog of cancer driver mutations in protein-coding genes has greatly expanded in the past decade. However, non-coding cancer driver mutations are less well-characterized and only a handful of recurrent non-coding mutations, most notably TERT promoter mutations, have been reported. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancer across 38 tumor types, we perform multi-faceted pathway and network analyses of non-coding...
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