Cerebral white matter structure is associated with DSM-5 schizophrenia symptom dimensions.

Katharina Stegmayer, Werner Strik, Petra Viher, Roland Wiest, Stephan Bohlhalter, Tim Vanbellingen, Stéphanie Giezendanner, Andrea Federspiel & Sebastian Walther
Diffusion tensor imaging (DTI) studies have provided evidence of widespread white matter (WM) abnormalities in schizophrenia. Although these abnormalities appear clinically significant, the relationship to specific clinical symptoms is limited and heterogeneous. This study examined the association between WM microstructure and the severity of the five main DSM-5 schizophrenia symptom dimensions. DTI was measured in forty patients with schizophrenia spectrum disorders. Using Tract-Based Spatial Statistics controlling for age, gender and antipsychotic dosage, our analyses revealed...
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