Mechanism and Function of Nascent Protein Modification in Bacteria

Chien-I Yang
Newly synthesized proteins undergo multiple modifications to ensure proper biogenesis and acquire their functions. N-terminal methionine excision (NME), mediated by the sequential actions of peptide deformylase (PDF) and methionine aminopeptidase (MAP), is an essential and the most prevalent N-terminal protein modification in the bacterial proteome. Despite the extensive studies on enzymatic catalysis, how NME impacts various cellular functions and how the enzymes achieve timing and selectivity under complex cellular conditions have been long-standing puzzles. In...
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