Whacked and Rab35 polarize dynein-motor-complex-dependent seamless tube growth

Jodi Schottenfeld-Roames & Amin S. Ghabrial
Seamless tubes form intracellularly without cell–cell or autocellular junctions. Such tubes have been described across phyla, but remain mysterious despite their simple architecture. In Drosophila, seamless tubes are found within tracheal terminal cells, which have dozens of branched protrusions extending hundreds of micrometres. We find that mutations in multiple components of the dynein motor complex block seamless tube growth, raising the possibility that the lumenal membrane forms through minus-end-directed transport of apical membrane components along...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.