Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer’s Disease: Results from the DIAN Study Group

Yi Su, Tyler M. Blazey, Christopher J. Owen, Jon J. Christensen, Karl Friedrichsen, Nelly Joseph-Mathurin, Qing Wang, Russ C. Hornbeck, Beau M. Ances, Abraham Z. Snyder, Lisa A. Cash, Robert A. Koeppe, William E. Klunk, Douglas Galasko, Adam M. Brickman, Eric McDade, John M. Ringman, Paul M. Thompson, Andrew J. Saykin, Bernardino Ghetti, Reisa A. Sperling, Keith A. Johnson, Stephen P. Salloway, Peter R. Schofield, Colin L. Masters … & Tammie L. S. Benzinger
Amyloid imaging plays an important role in the research and diagnosis of dementing disorders. Substantial variation in quantitative methods to measure brain amyloid burden exists in the field. The aim of this work is to investigate the impact of methodological variations to the quantification of amyloid burden using data from the Dominantly Inherited Alzheimer’s Network (DIAN), an autosomal dominant Alzheimer’s disease population. Cross-sectional and longitudinal [11C]-Pittsburgh Compound B (PiB) PET imaging data from the DIAN...
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