Whole Population, Genomewide Mapping of Hidden Relatedness

Alexander Gusev, Jennifer K. Lowe, Markus Stoffel, Mark Daly, David Altshuler, Jeffrey M. Friedman, Jan L. Breslow & Itshack G. Pe'er
The ability to identify and quantify genealogical relationships between individuals within a population is an important step in accurately using such data for disease analysis and improving our understanding of demography. However, exhaustive pair-wise analysis which has been successful in small cohorts cannot keep up with the current torrent of genotype data. We present GERMLINE, a robust algorithm for identifying pairwise segmental sharing which scales linearly with the number of input individuals. Our approach is...
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