Methodological Issues in Clinical Drug Development for Essential Tremor

Michael A. Carranza, Madeline R. Snyder, Rodger J. Elble, Angelique E. Boutzoukas & Theresa A. Zesiewicz
Essential tremor (ET) is one of the most common tremor disorders in the world. Despite this, only two medications have received Level A recommendations from the American Academy of Neurology to treat it (primidone and propranolol). Even though these medications provide relief to a large group of ET patients, up to 50% of patients are non-responders. Additional medications to treat ET are needed. This review discusses some of the methodological issues that should be addressed...
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