336 Works

BIOINFORMATIC AND EXPERIMENTAL ANALYSES OF AXOLOTL REGENERATION

Nour Al Haj Baddar
Salamanders have an extraordinary ability to regenerate appendages after loss or amputation, irrespective of age. My dissertation research explored the possibility that regenerative ability is associated with the evolution of novel, salamander-specific genes. I utilized transcriptional and genomic databases for the axolotl to discover previously unidentified genes, to the exclusion of other vertebrate taxa. Among the genes identified were multiple mmps (Matrix metalloproteases) and a jnk1/mapk8 (c-jun-N-terminal kinase) paralog. MMPs function in extracellular matrix remodeling...

Nanomaterials for Double-Stranded RNA Delivery

Stuart Lichtenberg
RNA interference has enormous potential as a potent, specific, and environmentally friendly alternative to small molecule pesticides for crop protection. The use of exogenous double-stranded RNA offers flexibility in targeting and use in crops in which transgenic manipulation is not an option. The combination of RNAi with nanotechnology offers further advantages that are not available with dsRNA alone. In this work, I have evaluated several different combinations of nanomaterials and polymers for use in RNAi-based...

PRINCIPAL BEHAVIORS THAT FOSTER COLLECTIVE EFFICACY AMONG TEACHERS IN RURAL SECONDARY SCHOOLS IN KENTUCKY

Tanya Jo Jury
The purpose of this study was to examine principal behaviors, identified by teachers and principals, which foster collective efficacy among teachers. As instructional leaders of a school, principals are expected to lead their schools. Behaviors exhibited by the principal can either help or hinder the success of the school and teachers and students in that school. This study will assist principals, aspiring principals, and instructors of principal preparation programs in knowing what behaviors are necessary...

EFFECTS OF NATURALISTIC TIME DELAY ON PROMOTING FUNCTIONAL REQUESTS USING AAC IN PRESCHOOLERS WITH AUTISM SPECTRUM DISORDERS

Brianna Rinaldi
The purpose of this study was to teach preschool children with autism spectrum disorders to make requests with a speech generating device using a naturalistic time delay prompting procedure. The participants in this study were two males, enrolled in a public preschool program, between four and five years old. Both participants showed significant delays in expressive communication requiring alternative and augmented communication. The study utilized a multiple probe design across behaviors. Results showed utilizing naturalistic...

SINGLE-DEGREE-OF-FREEDOM EXPERIMENTS DEMONSTRATING ELECTROMAGNETIC FORMATION FLYING FOR SMALL SATELLITE SWARMS USING PIECEWISE-SINUSOIDAL CONTROLS

Ajin Sunny
This thesis presents a decentralized electromagnetic formation flying (EMFF) control method using frequency-multiplexed sinusoidal control signals. We demonstrate the EMFF control approach in open-loop and closed-loop control experiments using a single-degree-of-freedom testbed with an electromagnetic actuation system (EAS). The EAS sense the relative position and velocity between satellites and implement a frequency-multiplexed sinusoidal control signal. We use a laser-rangefinder device to capture the relative position and an ARM-based microcontroller to implement the closed-loop control algorithm....

EFFECTS OF CURCUMIN AND FENUGREEK SOLUBLE FIBER SUPPLEMENTS ON SUBMAXIMAL AND MAXIMAL AEROBIC PERFORMANCE INDICES IN UNTRAINED COLLEGE-AGED SUBJECTS

Jensen Goh
Submaximal exercise performance is, in part, limited by the accumulation of metabolic byproducts and energy system capacities. Curcumin and the combination of curcumin and fenugreek soluble fiber (CurQfen®) have been shown to increase endogenous antioxidants and metabolic byproduct clearance as well as reduce inflammation and lipid peroxidation, and therefore, may enhance submaximal aerobic thresholds. In addition, there is evidence that the galactomannan component of fenugreek, used to enhance bioavailability of curcumin, may also have potential...

An Inverse Eigenvalue Problem for the Schrödinger Equation on the Unit Ball of R3

Maryam Ali Al Ghafli
The inverse eigenvalue problem for a given operator is to determine the coefficients by using knowledge of its eigenfunctions and eigenvalues. These are determined by the behavior of the solutions on the domain boundaries. In our problem, the Schrödinger operator acting on functions defined on the unit ball of $\mathbb{R}^3$ has a radial potential taken from $L^2_{\mathbb{R}}[0,1].$ Hence the set of the eigenvalues of this problem is the union of the eigenvalues of infinitely many...

Developmental Sequelae in Language, Empathy, Self-Control, and Psychopathy from Infancy to Middle Adolescence

Magda Javakhishvili
The present empirical work aims to discern the underlying mechanisms of purported developmental links among several key human characteristics including language skills, self-control, empathy, and psychopathic traits. Accordingly, three interrelated studies are carried out testing the longitudinal associations of various kinds (e.g., direct, indirect, bidirectional) among these constructs. All three studies are conceptually framed in consideration of the extant research and relevant theories. They employ the data set provided by the National Institute of Child...

MICROALGAE AND ZINC SOURCE SUPPLEMENTATION OF BROILER BREEDER DIETS AFFECTS BROILER BREEDER SKELETAL DEVELOPMENT AND REPRODUCTION WITH TRANSGENERATIONAL IMPACTS ON OFFSPRING PERFORMANCE AND SKELETAL CHARACTERISTICS

Marquisha A. Paul
Leg problems and disorders are of major concern for the poultry industry and animal welfare. Previous studies suggest that it may be possible to improve skeletal characteristics through nutrition. Omega-3 fatty acids, including Docosahexaenoic acid (DHA), are essential nutrients and are known to play an important role in bone tissue development. FORPLUS™ (Alltech, Inc.) is an unextracted, whole-cell microalgae (Aurantiochytrium limacinum CCAP 4087/2) that contains 64% fat and 16% DHA. Zinc (Zn) is a trace...

Pilot Study of Text Message Nudges as a Way to Improve Weight Loss Outcomes

Madison Copher
Weight loss programs for women are on the rise, including both face to face and online programs. However, current research is limited on the process measures and content which produce adherence and the largest outcomes. With obesity on the rise in the United States, it is important to understand out health coaches can strengthen their programs to better support the obese population in their weight loss journey. The purpose of this pilot study was to...

VITAL RATES AND HABITAT SELECTION OF BULL ELK (CERVUS CANADENSIS NELSONI) IN SOUTHEAST KENTUCKY

John Hast
Globally, male ungulate species are heavily managed for their sporting and trophy qualities. North American elk (Cervus canadensis) are typically managed using a male-biased harvest regime, placing increased chances of mortality on males in these hunted populations. To manage for trophy quality animals that typically represent older age classes, wildlife managers have implemented many age-biased harvest regulations, including spike-only tags and antler point restrictions. Many of these age-biased harvest regulations have fallen short of their...

EXPOSING CORRUPTION IN PROGRESSIVE ROCK

Robert Jacob Sivy
English progressive rock band Gentle Giant is catalogued under the progressive (or “prog”) rock genre for a variety reasons, including unique instrumentation, virtuosity, and interesting/unconventional musical attributes. The complexity of their music is often warranted by the sophisticated concepts behind their albums and the deep messages of their songs. The Power and the Glory (TPatG), Gentle Giant’s sixth studio album, is a concept album that emphasizes the rise and corruption of power. What makes their...

THE ROLE OF ENDOPLASMIC RETICULUM STRESS IN ETHANOL-INDUCED NEURODEGENERATION

yongchao wang
Heavy ethanol use causes neurodegeneration manifested by neuronal loss and dysfunction. It is becoming imperative to delineate the underlying mechanism to promote the treatment of ethanol-induced neurodegeneration. Endoplasmic reticulum (ER) stress is a hallmark and an underlying mechanism of many neurodegenerative diseases. This study aims to investigate the role of ER stress in ethanol-induced neurodegeneration. In experimental design, adult mice were exposed to binge ethanol drinking by daily gavage for 1, 5, or 10 days...

DEVELOPMENTAL CHANGES IN THE PIG FROM BIRTH TO 42 DAYS POST-WEANING (1.5 – 25 KILOGRAMS BODYWEIGHT)

Sarah Elefson
This study evaluated the changes in body composition, glycogen tissue reserves, visceral organ growth, and small intestine morphology in the young pig. A total of 96 crossbred pigs were euthanized at birth (pre-suckle), days 1, 2, 3, 5, 7, 14 postpartum, weaning at day 21, and days 1, 2, 3, 5, 7, 14, 28, and 42 post-weaning. Body composition of the pig had increasing dry matter and fat, decreasing ash, calcium and phosphorus, and relatively...

OPTIMIZING COVER CROP ROTATIONS FOR WATER, NITROGEN AND WEED MANAGEMENT

Cintia Soledad Sciarresi
Winter cover crops grown in rotation with grain crops can be an efficient integrated pest management tool (IPM). However, cover crop biomass production and thus successful provisioning of ecosystem services depend on a timely planting and cover crop establishment after harvest of a cash crop in the fall. One potential management adaptation is the use of short-season soybeans to advance cover crop planting date in the fall. Cover crops planted earlier in the fall may...

EFFECT OF BEDDING TYPE AND SOIL INCORPORATION ON NITROGEN MINERALIZATION RATE OF BROILER LITTER AMENDED SOILS

Lydia Fitzgerald
Broiler litter (BL) is a high value manure available to Kentucky crop producers to utilize as a fertilizer. The rate of BL application, timing of application, and method of application are all important factors to take into account when utilizing BL. A laboratory incubation was conducted to observe nitrogen (N) mineralization rates of BL amended soils over time under different conditions. Different application methods, application rates, watering frequencies, and bedding materials were used to determine...

BINARY BRIGHT-LINE DECISION MODELS FOR GOING CONCERN ASSESSMENT

Sid Bundy
In August, 2014, the Financial Accounting Standards Board issued an update concerning the disclosure of uncertainties about an entity’s ability to continue as a going concern. The standard requires an entities management to evaluate whether there is substantial doubt about the entity’s ability to continue as a going concern and to provide related footnote disclosures in certain circumstances. One consequence of this regulation is the need for guidance for audit testing of management’s assessments in...

THE EFFECTS OF CURCUMIN AND FENUGREEK SOLUBLE FIBER ON THE PHYSICAL WORKING CAPACITY AT THE FATIGUE THRESHOLD, PEAK OXYGEN CONSUMPTION, AND TIME TO EXHAUSTION

Lauren Herrick
Curcumin, a polyphenol, has been suggested to improve metabolic byproduct clearance and increasenitric oxide productionin working muscle. These purported effects may delay neuromuscular fatigue. Therefore, the purpose of this study was to examine the effects of curcuminin combination with fenugreek (CUR) or fenugreek soluble fiber alone (FEN)on the neuromuscular fatigue threshold (PWCFT), time to exhaustion (Tlim) on a graded exercise test (GXT), and 𝑉̇O2peakin untrained subjects. Forty-seven,college-aged, aerobically untrained individuals were randomly assigned to one...

HIGH SCHOOL ENGINEERING STUDENTS’ IDENTITIES AND INTEREST IN STEM

Morgan Lane
With a national push toward improving STEM education, it is imperative for researchers to study what makes students want to pursue STEM education and STEM careers. To learn about this in the context of one high school’s engineering program, this study used student interviews to gain insight into how student identities influence their interest and experiences in STEM. Five components of student identities were revealed to be influential on a student’s interest in STEM:(1)an early...

Major Lower Paleozoic Horizons of the Southern Illinois Basin

John B. Hickman
The geology exposed at the surface in the southern Illinois Basin has been mapped in great detail by countless workers over the past century. With the exception of limited and scattered exposures in incised river valleys, the oldest rocks exposed outside of the Jessamine, Nashville, and Ozark Domes surrounding the Illinois Basin are Mississippian in age. Extensive deposits of Cambrian–Devonian sediments occur in the subsurface above crystalline basement in this region, however. All available data...

Rapid Retrofit and Strengthening of Bridge Components

Abheetha Peiris & Issam E. Harik
Rapid repair of damaged or deteriorated concrete bridge components will prevent the entire bridge from suffering irreversible damage in the future due to gradual spalling of concrete or corrosion of exposed steel. CFRP laminates and fabrics have become popular for repairing and strengthening of concrete girders. A series of CFRP materials — branded CatStrong — specifically designed for the repair and retrofit of bridges was developed at the Kentucky Transportation Center and the University of...

LONGITUDINAL DESCRIPTIVE PROFILE OF COLLEGIATE PITCHERS PARTICIPATING IN A SUMMER BASEBALL LEAGUE

Isabelle Leslie Gillis
The purpose of this study was to provide a longitudinal profile of pitching performance in a cohort of pitchers over two collegiate seasons and a summer league. Thus, this study utilized a longitudinal design to evaluate the impact of summer league participation on subsequent collegiate regular season pitching performance. Specifically, the performance of a cohort of Division 1 collegiate baseball pitchers during the 2018 Spring collegiate season, 2018 Summer League season, and the 2019 Spring...

The evolution of broadly polylectic behaviour in Lasioglossum (Chilalictus) (Halictidae, Apoidea)

Trace Akankunda, Carlos Rodriguez Lopez, Remko Leijs & Ken Walker
Based on the number of pollen hosts utilised, bees have been categorised as generalists (polylectic) or specialists (oligolectic). Faced with a changing habitat, polylectic bees can diversify their pollen ‘portfolio’, while oligolectic bees cannot and therefore may go locally extinct. Research into the evolution and maintenance of broad polylecty is scant. Instead, research has mainly focussed on the factors that constrain oligolectic species to a narrow diet. Here, we developed a molecular phylogeny of a...

Data from: Comparative genomic analysis of the pheromone receptor Class 1 family (V1R) reveals extreme complexity in mouse lemurs (genus, Microcebus) and a chromosomal hotspot across mammals

Kelsie E Hunnicutt, George P Tiley, Rachel C Williams, Peter A Larsen, Marina B Blanco, Rodin M Rasoloarison, Christopher Ryan Campbell, Kevin Zhu, David W Weisrock, Hiroaki Matsunami & Anne D Yoder
Sensory gene families are of special interest, both for what they can tell us about molecular evolution, and for what they imply as mediators of social communication. The vomeronasal type-1 receptors (V1Rs) have often been hypothesized as playing a fundamental role in driving or maintaining species boundaries given their likely function as mediators of intraspecific mate choice, particularly in nocturnal mammals. Here, we employ a comparative genomic approach for revealing patterns of V1R evolution within...

Data from: Nonconsumptive predator effects modify crayfish-induced bioturbation as mediated by limb loss: field and mesocosm experiments

Luc Dunoyer, Dakota Coomes & Philip Crowley
1. We addressed the implications of limb loss and regeneration for multi-species interactions and their impacts on ecosystem engineering in freshwater stream environments. 2. We included regenerative and non-regenerative crayfish as well as fish predators in a 2x2 factorial design to assess the effects on water turbidity of interactions between crayfish ecosystem engineers differing in regenerative status and their fish predators. 3. We demonstrated that crayfish limb loss and predation risks lead to more turbidity...

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