266 Works

Data from: Loss of murine Paneth cell function alters the immature intestinal microbiome and mimics changes seen in neonatal necrotizing enterocolitis

Shiloh R. Lueschow, Jessica Stumphy, Huiyu Gong, Stacy L. Kern, Timothy G. Elgin, Mark A. Underwood, Karen M. Kalanetra, David A. Mills, Melissa H. Wong, David K. Meyerholz, Misty Good & Steven J. McElroy
Necrotizing enterocolitis (NEC) remains the leading cause of gastrointestinal morbidity and mortality in premature infants. Human and animal studies suggest a role for Paneth cells in NEC pathogenesis. Paneth cells play critical roles in host-microbial interactions and epithelial homeostasis. The ramifications of eliminating Paneth cell function on the immature host-microbial axis remains incomplete. Paneth cell function was depleted in the immature murine intestine using chemical and genetic models, which resulted in intestinal injury consistent with...

Data from: Adaptive phenotypic plasticity in a clonal invader

Gerlien Verhaegen, Kyle E. McElroy, Laura Bankers, Maurine Neiman & Martin Haase
Organisms featuring wide trait variability and occurring in a wide range of habitats, such as the ovoviviparous freshwater New Zealand snail Potamopyrgus antipodarum, are ideal models to study adaptation. Since the mid-19th century, P. antipodarum, characterized by extremely variable shell morphology, has successfully invaded aquatic areas on four continents. Because these obligately and wholy asexual invasive populations harbor low genetic diversity compared to mixed sexual/asexual populations in the native range, we hypothesized that 1) this...

Data from: Genetic variation for mitochondrial function in the New Zealand freshwater snail Potamopyrgus antipodarum

Joel Sharbrough, Jennifer L. Cruise, Megan Beetch, Nicole M. Enright, Maurine Neiman, Nicole M Enright & Jennifer L Cruise
The proteins responsible for mitochondrial function are encoded by two different genomes with distinct inheritance regimes, rendering rigorous inference of genotype–phenotype connections intractable for all but a few model systems. Asexual organisms provide a powerful means to address these challenges because offspring produced without recombination inherit both nuclear and mitochondrial genomes from a single parent. As such, these offspring inherit mitonuclear genotypes that are identical to the mitonuclear genotypes of their parents and siblings and...

18 Artless Pages, 7 Impromptus for Piano. I. Romantic Etude (Staccato Etude)

Wenjuan Peng & Rodion Shchedrin
This project was completed for the Doctor of Music Arts degree at the University of Iowa School of Music.

Data from: De novo transcriptome characterization of a sterilizing trematode parasite (Microphallus sp.) from two species of New Zealand snails

Laura Bankers & Maurine Neiman
Snail-borne trematodes represent a large, diverse, and evolutionarily, ecologically, and medically important group of parasites, often imposing strong selection on their hosts and causing host morbidity and mortality. Even so, there are very few genomic and transcriptomic resources available for this important animal group. We help to fill this gap by providing transcriptome resources from trematode metacercariae infecting two congeneric snail species, Potamopyrgus antipodarum and P. estuarinus. This genus of New Zealand snails has gained...

Data from: Biophysical models reveal the relative importance of transporter proteins and impermeant anions in chloride homeostasis

Kira Michaela Düsterwald, Christopher Brian Currin, Richard Joseph Burman, Colin J. Akerman, Alan R. Kay & Joseph Valentino Raimondo
Fast synaptic inhibition in the nervous system depends on the transmembrane flux of Cl- ions based on the neuronal Cl- driving force. Established theories regarding the determinants of Cl- driving force have recently been questioned. Here we present biophysical models of Cl- homeostasis using the pump-leak model. Using numerical and novel analytic solutions, we demonstrate that the Na+/K+-ATPase, ion conductances, impermeant anions, electrodiffusion, water fluxes and cation-chloride cotransporters (CCCs) play roles in setting the Cl-...

Data from: Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate

Zena T. Wolf, Harrison A. Brand, John R. Shaffer, Elizabeth J. Leslie, Boaz Arzi, Cali E. Willet, Timothy C. Cox, Toby McHenry, Nicole Narayan, Eleanor Feingold, Xioajing Wang, Saundra Sliskovic, Nili Karmi, Noa Safra, Carla Sanchez, Frederic W. B. Deleyiannis, Jeffrey C. Murray, Claire M. Wade, Mary L. Marazita & Danika L. Bannasch
Cleft lip with or without cleft palate (CL/P) is the most commonly occurring craniofacial birth defect. We provide insight into the genetic etiology of this birth defect by performing genome-wide association studies in two species: dogs and humans. In the dog, a genome-wide association study of 7 CL/P cases and 112 controls from the Nova Scotia Duck Tolling Retriever (NSDTR) breed identified a significantly associated region on canine chromosome 27 (unadjusted p=1.1 x 10-13; adjusted...

Data from: Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid

Ximena Steinberg, Marina A. Kasimova, Deny Cabezas-Bratesco, Jason D. Galpin, Ernesto Ladron-De-Guevara, Federica Villa, Vincenzo Carnevale, Leon Islas, Christopher A. Ahern, Sebastian Brauchi, Jason D Galpin, Christopher A Ahern, Marina A Kasimova & Sebastian E Brauchi
TRPV1 channels support the detection of noxious and nociceptive input. Currently available functional and structural data suggest that TRPV1 channels have two gates within their permeation pathway: one formed by a ′bundle-crossing′ at the intracellular entrance and a second constriction at the selectivity filter. To describe conformational changes associated with channel gating, the fluorescent non-canonical amino acid coumarin-tyrosine was genetically encoded at Y671, a residue proximal to the selectivity filter. Total internal reflection fluorescence microscopy...

Data from: The neuropathic diabetic foot ulcer microbiome is associated with clinical factors.

Sue E. Gardner, Stephen L. Hillis, Kris Heilmann, Julia A. Segre, Elizabeth A. Grice, J. A. Segre, S. E. Gardner, S. L. Hillis, K. Heilmann & E. A. Grice
Nonhealing diabetic foot ulcers (DFUs) are a common and costly complication of diabetes. Microbial burden, or "bioburden," is believed to underlie delayed healing, although little is known of those clinical factors that may influence microbial load, diversity, and/or pathogenicity. We profiled the microbiomes of neuropathic nonischemic DFUs without clinical evidence of infection in 52 individuals using high-throughput sequencing of the bacterial 16S ribosomal RNA gene. Comparatively, wound cultures, the standard diagnostic in the clinic, vastly...

01 Open

Christine Augspurger & Taylor Ambrosio Wood
Transience: The Music of Taylor Ambrosio Wood. Track One. This project was completed for the Doctor of Music Arts degree at the University of Iowa School of Music.

Data from: Characterization of transcriptomes from sexual and asexual lineages of a New Zealand snail (Potamopyrgus antipodarum)

Peter R. Wilton, Daniel B. Sloan, John M. Logsdon, Harshavardhan Doddapaneni, Maurine Neiman & Logsdon Jr, John M.
Understanding the evolution and maintenance of sexual reproduction is one of the central challenges of evolutionary biology, yet we know very little about how sex influences molecular evolution. The New Zealand freshwater snail Potamopyrgus antipodarum is ideally suited to address this knowledge gap because obligately sexual individuals often coexist with multiple independently derived obligately asexual lineages. This unusual situation allows direct comparisons both between sexual and asexual P. antipodarum and across populations that differ in...

Data from: Inference of chromosomal inversion dynamics from Pool-Seq data in natural and laboratory populations of Drosophila melanogaster

Martin Kapun, Hester Van Schalkwyk, Bryant McAllister, Thomas Flatt & Christian Schlötterer
Sequencing of pools of individuals (Pool-Seq) represents a reliable and cost-effective approach for estimating genome-wide SNP and transposable element insertion frequencies. However, Pool-Seq does not provide direct information on haplotypes so that for example obtaining inversion frequencies has not been possible until now. Here, we have developed a new set of diagnostic marker SNPs for 7 cosmopolitan inversions in Drosophila melanogaster that can be used to infer inversion frequencies from Pool-Seq data. We applied our...

Data from: Developmental 'awakening' of primary motor cortex to the sensory consequences of movement

James C Dooley & Mark S Blumberg
Before primary motor cortex (M1) develops its motor functions, it functions like a somatosensory area. Here, by recording from neurons in the forelimb representation of M1 in postnatal day (P) 8-12 rats, we demonstrate a rapid shift in its sensory responses. At P8-10, M1 neurons respond overwhelmingly to feedback from sleep-related twitches of the forelimb, but the same neurons do not respond to wake-related movements. By P12, M1 neurons suddenly respond to wake movements, a...

Data from: Developmental changes in hippocampal CA1 single neuron firing and theta activity during associative learning

Jangjin Kim, Mary E. Goldsberry, Thomas C. Harmon & John H. Freeman
Hippocampal development is thought to play a crucial role in the emergence of many forms of learning and memory, but ontogenetic changes in hippocampal activity during learning have not been examined thoroughly. We examined the ontogeny of hippocampal function by recording theta and single neuron activity from the dorsal hippocampal CA1 area while rat pups were trained in associative learning. Three different age groups [postnatal days (P)17-19, P21-23, and P24-26] were trained over six sessions...

03 Les Heures dolentes III. Du soleil au jardin

Bo Ties & Gabriel Dupont
This project was completed for the Doctor of Music Arts degree at the University of Iowa School of Music.

17 Second Improvisation, Op. 47, Variations XIV-XV: “Song of the Water Nymph,” “Stormy Weather,” and “Conclusion”

Aleksandr Ponomarchuk & Nikolai Medtner
This project was completed for the Doctor of Music Arts degree at the University of Iowa School of Music.

unearthing edges : constructing gaps

Ailey Picasso
This project was completed for the Master of Fine Arts in Dance degree at the University of Iowa.

10 Close

Christine Augspurger & Taylor Ambrosio Wood
Transience: The Music of Taylor Ambrosio Wood. Track Ten. This project was completed for the Doctor of Music Arts degree at the University of Iowa School of Music.

21 Water Melody

Tieyi Zhang & Shengxi Lin
This project was completed for the Doctor of Music Arts degree at the University of Iowa School of Music.

01 Questions, 11 Pieces for Piano. I.

Wenjuan Peng & Rodion Shchedrin
This project was completed for the Doctor of Music Arts degree at the University of Iowa School of Music.

04 The Three Wishes of the Rose (1933)

Tieyi Zhang & Zi Huang
This project was completed for the Doctor of Music Arts degree at the University of Iowa School of Music.

01 Les Heures dolentes I. Epigraphe

Bo Ties & Gabriel Dupont
This project was completed for the Doctor of Music Arts degree at the University of Iowa School of Music.

22 Small Pathway (1947)

Tieyi Zhang & Xiaolin Tan
This project was completed for the Doctor of Music Arts degree at the University of Iowa School of Music.

02 Symphony in E Minor, Op. 67, “Es muβ doch Frühling werden”, II. Adagio

Pui Yan Ronald Lau & Ferdinand Hiller
This project was completed for the Doctor of Music Arts degree at the University of Iowa School of Music.

06 Song of Divination: Ode to the Plum Blossom (1964)

Tieyi Zhang & Luting He
This project was completed for the Doctor of Music Arts degree at the University of Iowa School of Music.

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