3 Works

Data from: Penalized Multi-Marker versus Single-Marker Regression methods for genome-wide association studies of quantitative traits

Hui Yi, Patrick Breheny, Netsanet Iman, Yongmei Liu, Ina Hoeschele, H. Yi, N. Imam, I. Hoeschele & P. Breheny
The data from genome-wide association studies (GWAS) in humans are still predominantly analyzed using single marker association methods. As an alternative to Single Marker Analysis (SMA), all or subsets of markers can be tested simultaneously. This approach requires a form of Penalized Regression (PR) as the number of SNPs is much larger than the sample size. Here we review PR methods in the context of GWAS, extend them to perform penalty parameter and SNP selection...

Data from: Sequential adaptive introgression of the mitochondrial genome in Drosophila yakuba and D. santomea

Ana Llopart, Danielle Herrig, Evgeny Brud & Zachary Stecklein
Interspecific hybridization provides the unique opportunity for species to tap into genetic variation present in a closely related species and potentially take advantage of beneficial alleles. It has become increasingly clear that when hybridization occurs, mitochondrial DNA (mtDNA) often crosses species boundaries, raising the possibility that it could serve as a recurrent target of natural selection and source of species’ adaptations. Here we report the sequences of 46 complete mitochondrial genomes of Drosophila yakuba and...

Data from: The neuropathic diabetic foot ulcer microbiome is associated with clinical factors.

Sue E. Gardner, Stephen L. Hillis, Kris Heilmann, Julia A. Segre, Elizabeth A. Grice, J. A. Segre, S. E. Gardner, S. L. Hillis, K. Heilmann & E. A. Grice
Nonhealing diabetic foot ulcers (DFUs) are a common and costly complication of diabetes. Microbial burden, or "bioburden," is believed to underlie delayed healing, although little is known of those clinical factors that may influence microbial load, diversity, and/or pathogenicity. We profiled the microbiomes of neuropathic nonischemic DFUs without clinical evidence of infection in 52 individuals using high-throughput sequencing of the bacterial 16S ribosomal RNA gene. Comparatively, wound cultures, the standard diagnostic in the clinic, vastly...

Registration Year

  • 2014
    3

Resource Types

  • Dataset
    3

Affiliations

  • University of Iowa
    3
  • University of Pennsylvania
    1
  • National Institutes of Health
    1
  • Virginia Tech
    1