Invasive physiological stenosis assessment is recommended to identify myocardial ischemia and guide percutaneous coronary intervention (PCI) in patients with stable coronary artery disease (CAD). The therapeutic aims of PCI in stable CAD are to relieve ischemia, resolve angina symptoms and improve exercise capacity. However, the relationship between physiological stenosis severity (i.e. the diagnostic test) and angina-limited exercise capacity (i.e. the therapeutic target) is poorly understood. Accordingly, this represents an important gap in knowledge relevant to...
Although technological start-ups are at the core of the debate about fostering job creation and wealth, many studies remain theoretical and are unable to provide practical information to founders. Consequently, much of the knowledge used by new technology-based firms comes from anecdotal evidence. The research reported here focuses on closing the gap between theory and practice, and includes the creation of models that support the decision-making process in technological start-ups. This thesis shares several contributions...
This thesis begins with a literature review of lithium-ion battery behaviour. Emphasis is placed on thermodynamics, kinetics and the reversible lithium plating reaction. Advancements made to the battery simulation software LIONSIMBA, resulting in the creation of v2.0, are presented. With LIONSIMBA as one component, a framework is developed and demonstrated for the optimal balancing of cell energy and power density in electric vehicles. Vehicle simulations are performed for acceleration and fast charging. The framework thus...
The gut microbiota has far-reaching effects on health and may influence immune responses in the airways through the gut/lung axis and yet, despite their high prevalence, little is known about how respiratory viral infections affect the gut microbiota. This study investigated the effect of respiratory syncytial virus (RSV) and influenza A virus infection on the gut microbiota using mouse models and 16S rRNA gene sequencing on faecal samples. RSV and influenza virus infection were both...
This thesis is a collection of various results related to the arithmetic of K3 surfaces and hypersurfaces which were obtained by the author during the course of his PhD studies. The first part is related to Artin's conjecture on hypersurfaces over p-adic fields and solves the following question using tools from logarithmic geometry: Let f:X->Y be a proper, dominant morphism of smooth varieties over a number field k. When is it true that for almost...
C2 Quintet CASSCF(8,8, Nroot=2)/Def2QZVPP alter 7 9 C=C stretching wavenumber = 1539 cm-1 G = -75.417310 with Natural orbitalsHenry Rzepa
Gaussian Calculation Force constant 16.7461 mdyne/A
This guide has been created by bibliometric practitioners to support other users of InCites and promote a community of informed and responsible use. The recommendations in this document may be more suited to other academic sector users, but the authors hope that other users may also benefit from the suggestions. The guide aims to provide plain-English definitions, key strengths and weaknesses and some practical application tips for some of the most commonly-used indicators available in...
Augmented reality is an important tool for surgical training and skills assessment. The use of computer simulation, particularly the reliance on patient specific data for building realistic models both in terms of biomechanical fidelity and photorealism has attracted extensive interests in recent years. For example, by fusing real bronchoscopy video with 3D tomographic data with the same patient, it is possible to generate photorealistic models that allow high fidelity, patient specific bronchoscope simulation. In order...
This report includes data for Imperial College London APC payments made from 1 January 2015 to 30 June 2015. As a part of its work on negotiating the Total Cost of Ownership with journal publishers, Jisc Collections has been gathering and openly releasing data on article processing charge (APC) payments made by UK higher education institutions (HEIs). Making this data openly available has helped to raise awareness of the amount of money being paid for...
This report includes data for Imperial College London APC payments made from 1 January 2016 to 31 December 2016. As a part of its work on negotiating the Total Cost of Ownership with journal publishers, Jisc Collections has been gathering and openly releasing data on article processing charge (APC) payments made by UK higher education institutions (HEIs). Making this data openly available has helped to raise awareness of the amount of money being paid for...
This is the annual report to COAF of APC spend from the COAF fund between 01/10/2014 and 30/09/2015.
This is the annual report to COAF of APC spend from the COAF fund between 01/10/2015 and 30/09/2016.
This is the annual report to COAF of APC spend from the COAF fund between 01/10/2016 and 30/09/2017.
This is the annual report to COAF of APC spend from the COAF fund between 01/10/2017 and 30/09/2018. It also includes details of an overspend on the 2016-17 grant carried over to this year's funds.
This is the annual report to COAF of APC spend from the COAF fund between 01/10/2018 and 30/09/2019. The supplement 1 and supplement 2 tabs detail spend from extra funds provided by the Wellcome Trust when the main fund was exhausted.
This report includes data for Imperial College London APC payments made from 1 January 2018 to 31 March 2019. As a part of its work on negotiating the Total Cost of Ownership with journal publishers, Jisc Collections has been gathering and openly releasing data on article processing charge (APC) payments made by UK higher education institutions (HEIs). Making this data openly available has helped to raise awareness of the amount of money being paid for...
The flagship publication of Imperial College London's Grantham Institute - Climate Change and the Environment, which showcases how the institute is tackling the challenges of climate and environmental change.
Laparoscopic surgery, a form of Minimally Invasive Surgery (MIS), presents many challenges to surgeons in terms of instrument control, manual dexterity, and hand-eye coordination. The current training and assessment regime is subjective and there is an increasing demand for objective measurement of surgical skills. Existing research into laparoscopic surgery reveals many psychomotor challenges to the surgeon, highlighting the importance of adequate training and assessment of laparoscopic skills. This thesis addresses the problem of objective assessment...
Changes in cardiac structure and contractile performance are key indicators for the early detection of heart disease, the leading cause of premature death in the western world. Accurate assessment of the low-level function of the contractile tissue of the heart, the myocardium, has the potential to provide a valuable tool for the prevention, diagnosis and treatment of these conditions, and key to this process are techniques to accurately measure in vivo tissue motion across the...
Climate change is already happening, and the UK’s climate will continue to change as a result of greenhouse gas emissions, with the long-term resilience of its infrastructure at risk. The water sector cannot adapt to the challenges of climate change in isolation, as policy effects in one sector will have indirect effects in others. Current demand pressures and reductions in abstraction licences – rights to draw water – are causing supply-demand deficits and this is...
Uptake and metabolism of four isomers of dinitrotoluene in A. thaliana and their sequestration in feeding aphids: a phytoremediation perspectiveNumrah Nisar
Plants, being sessile, have wide variety of metabolic pathways to detoxify hazardous compounds therefore ensuring the success of phytoremediation of a wide variety of xenobiotics. One such a compound is dinitrotoluene (DNT) that is available as a mixture of six different isomers. Phytoremediation of DNTs is a cost effective, eco friendly and preferable approach compared to commercially available chemical and physical remediation systems. DNTs are toxic to plants at higher concentrations, however lower concentrations are...
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