14,765 Works

Investigating viral protein U (Vpu) of HIV-1 using all-atom molecular dynamics

Shukai Wang
Viral Protein U (Vpu) is an accessory protein of the HIV-1 virus and a member of the Viral Channel Forming protein (VCP) family. A HIV-1 virus with Vpu is 10 times more infectious than a Vpu deficient HIV-1 virus. Vpu consists of 81 amino acids, with one transmembrane (TM) helix close to the N-terminus and two cytoplasmic (Cyto) helices. It is involved in more than ten different activities. The most well studied functions are CD4...

Control of clogging in permeable concrete pavements

Alalea Kia
This thesis aims to improve the understanding of clogging and the effects this has on permeable concrete, and to develop new permeable concretes that are more durable and resistant to clogging without the need for frequent maintenance. Permeable concrete, also known as pervious concrete, is used to reduce urban flooding as it allows water to flow through normally impermeable infrastructure. It is prone to clogging by particulate matter and predicting the long-term performance of permeable...

Essays on investment and portfolio management of hedge funds

Chao Zhang
This thesis is made up of three independent chapters on hedge fund investment and portfolio management. This thesis aims to shed light on the investment skills of hedge fund managers in the U.S. stock market and convertible bond market, and the funding liquidity risk of hedge funds. Chapter 2 investigates the preference and investment skills of Equity Long/Short and Equity Market Neutral hedge fund managers in the U.S. equity market from March 1997 to December...

Mechanisms of evasion of the African Trypanosome: Trypanosoma brucei from the host innate and adaptive immune system

Jackie Lok-Yee Cheung
The extracellular bloodstream form Trypanosoma brucei is the causative agent of Human African Trypanosomiasis (HAT). It is highly adapted to escape both the innate and adaptive immune systems of the mammalian host, which is mediated through a dense Variant Surface Glycoprotein (VSG) coat. Two main mechanisms of evasion are known to provide protection for the parasite in the bloodstream: antigenic variation and high rates of host opsonin removal. VSG is essential for trypanosome survival and...

Trajectory and sequence analysis of administrative data

Ahsan Mumtaz Rao
Health policy makers struggle to curb readmission rates despite various health policies. The National Health Service is spending more than half of its healthcare budget to manage emergency inpatient admissions. There is a subgroup of patients who use disproportionately more health resources and have higher rates of unplanned hospitalisation. They are defined as high-impact users. The characteristics and long-term healthcare use of high-impact users are poorly understood. Previous methods and models to identify and predict...

Silicon-containing COFs and MOFs for CO2 capture

Okpara Sergeant Bull
This work was conducted in order to explore the potential of novel silicon-based Covalent Organic Frameworks (COFs) and Metal-Organic Frameworks (MOFs) for CO2 capture. A Lewis acid, cyclo-1,3,3,5,7,7-hexaphenyl-1,5-dibora-3,7-disiloxane (3) was synthesized and complexed with a variety of Lewis bases such as 4,4╦łbipyridine (L1), 1,2-di(pyridin-4- yl)ethane (L2), 1,2-di(pyridin-4-yl)ethene (L3), 1,3-di(pyridin-4-yl)propane (L4), 1,2- di(pyridin-4-yl)sulfane (L5), 1,2-di(pyridin-4-yl)diazene (L6), 1,4-di(pyridin-4-yl)benzene (L7), 3,5-di(pyridin-3-yl)-1,2,4-thiadiazole (L8) and 3,5-di(pyridin-4-yl)-1,2,4-thiadiazole (L9) to afford a range of 1-D polymers such as as [Ph6B2Si2O4].L1 (4), [Ph6B2Si2O4].L2...

New synthetic approaches for metal salphens and development of microfluidic platforms to study their G-quadruplex binding

Viktoria Lena Rakers
Guanine-rich sequences are primarily found in the promoter region of several proto-oncogenes and in the telomeric region; they have been shown to readily fold into quadruple-stranded structures, termed G-quadruplexes, in vitro. Mounting experimental evidence suggests that these structures are involved in key biological processes like replication, transcription and telomere maintenance. A wide range of high-affinity binders has been presented in the literature, but the development of small molecule binders has been mostly limited to conventional...

Flexible instruments for a snake-like robot

Andreas Schmitz
Minimally Invasive Surgery (MIS) is a widely adopted technique due to the many advantages it holds for patients, e.g., reductions in healing times. In MIS one procedure within many is using a snakelike robot for scarless endoscopic surgery, such as gastrointestinal endoscopic surgery. In this type of surgery, the snake-like robot is inserted through a natural orifice and is directed towards a chosen surgical site. Once the robot is in place, small robotic instrument arms...

2-(2-bromo-4,6-bis(trifluoromethyl)phenyl)-4-chloropyridine

Henry Rzepa
1H NMR Data

NMR Data for Kinetic Benchmarking Reveals the Competence of Prenyl Groups in Ring-Closing Metathesis

Karim Bahou
NMR Data for 1H, 13C.

R_Lactone_Product_1 (opt freq)

Bethan Coulson
Gaussian Calculation

1-((2-isopropyl-4-nitrophenyl)sulfonyl)-2-(((triisopropylsilyl)oxy)methyl)indoline

Henry Rzepa
NMR Data

diol 14-S conf 2 H-bond atrop G=-1764.752782

Henry Rzepa
Gaussian Calculation

1-((2-isopropyl-4-nitrophenyl)sulfonyl)-5-methoxy-2-methylindoline

Henry Rzepa
NMR Data

Conf1, TPSSh/6-311g(2df,p) nstates=150

Henry Rzepa
Gaussian Calculation

Excel Documents

Karim Bahou
Excel Documents

Diethyl 2-(4-(allyloxy)-2-methylbut-2-en-1-yl)-2-(3-methylbut-2-en-1-yl)malonate

Karim Bahou
Diethyl 2-(4-(allyloxy)-2-methylbut-2-en-1-yl)-2-(3-methylbut-2-en-1-yl)malonate

Conf4, TPSSh/6-311g(2df,p) nstates=120

Henry Rzepa
Gaussian Calculation

dsdsds

Matthew Harvey

IRC_A_TS_1 (Zsilylenol ether) (IRC)

Bethan Coulson
Gaussian Calculation

Conf7, TPSSh/6-311g(2df,p) optrot

Henry Rzepa
Gaussian Calculation

Conf8, TPSSh/6-311g(2df,p) optrot

Henry Rzepa
Gaussian Calculation

Methanol in methanol, mpw1pw91/aug-cc-pvdz

Henry Rzepa
Gaussian Calculation

1-((2-isopropyl-4-nitrophenyl)sulfonyl)-2-methylindoline

Henry Rzepa
NMR Data

2-(((triethylsilyl)oxy)methyl)indoline

Henry Rzepa
NMR Data

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