12,821 Works

Quantitative imaging of plasmid DNA in human airway epithelial cells following non-viral gene transfer

Charanjit Singh
The UK CF Gene Therapy Consortium is interested in non-viral gene therapy for cystic fibrosis (CF). To provide insight into the intracellular bottlenecks plasmid DNA (pDNA) encounters on its way to the nuclei of airway epithelial cells, I sought to quantitatively describe the intracellular fate of non-virally transferred pDNA using a clinically relevant human airway epithelial cell air-liquid-interface (ALI) model. Plasmid DNA was tagged with nanogold particles or fluorescent quantum dots (QDots) for use in...

Study to support the REFIT evaluation of Directive 2001/42/EC on the assessment of the effects of certain plans and programmes on the environment (SEA Directive) Final report

J McGuinn, L Oulès, P Banfi, A McNeill, S O’Brien, Z Lukakova, W Sheate, S Kolaric & R Sadauskis
This evaluation study supports the evaluation of Directive 2001/42/EC on the assessment of the effects of certain public plans and programmes on the environment (SEA Directive) as part of the European Commission's Regulatory Fitness Check and Performance (REFIT) programme. This assessment is based on five evaluation criteria: effectiveness, efficiency, relevance, coherence and EU added value. The study found that the SEA Directive brings considerable benefits to the EU, contributing to wider goals on sustainable development...

The arthroplasty candidacy help engine tool to select candidates for hip and knee replacement surgery: development and economic modelling

A Price, J Smith, H Dakin, S Kang, P Eibich, J Cook, A Gray, K Harris, R Middleton, E Gibbons, E Benedetto, S Smith, J Dawson, R Fitzpatrick, A Sayers, L Miller, E Marques, R Gooberman-Hill, A Blom, A Judge, N Arden, D Murray, S Glyn-Jones, K Barker, A Carr … & D Beard
Background There is no good evidence to support the use of patient-reported outcome measures (PROMs) in setting preoperative thresholds for referral for hip and knee replacement surgery. Despite this, the practice is widespread in the NHS. Objectives/research questions Can clinical outcome tools be used to set thresholds for hip or knee replacement? What is the relationship between the choice of threshold and the cost-effectiveness of surgery? Methods A systematic review identified PROMs used to assess...

Tidal modelling with Thetis: preliminary English Channel benchmarking

Z Goss, S Warder, A Angeloudis, S Kramer, A Avdis & M Piggott
This report describes the application and benchmarking of the Thetis coastal ocean model for tidal modelling, and makes use of a test case based upon the English Channel. Comparisons are made between model predictions and tide gauge data at a number of locations across the English Channel. A preliminary investigation of the impact of mesh resolution and bathymetry data is given. A demonstration is also provided of Thetis’s ability to use adjoint technology to optimise...

Lightmasks that prevent dark adaptation for non-central diabetic macular oedema: the CLEOPATRA RCT

S Sivaprasad, J Vasconcelos, H Holmes, C Murphy, J Kelly, P Hykin & A Prevost
Excerpt Background: Hypoxia may contribute to the development and progression of diabetic macular oedema (DMO) and diabetic retinopathy. The photoreceptors are the most metabolically active cells in the retina and the rod photoreceptors consume the maximal amount of oxygen for dark adaptation. Therefore, a lightmask emitting 500- to 505-nm light and worn at night during sleep may prevent rod-related dark adaptation and, thereby, reduce the retinal oxygen consumption and improve or prevent progression of DMO...

Chalk regional groundwater models and their applicability to site scale processes

Simon John Parker
Chalk is an important aquifer in England. Because of the highly permeable nature of the subsurface, groundwater moves relatively quickly, so that source area for a Chalk stream can change significantly on a seasonal basis. This research looks at both the hydrogeology at site scale and regional scale ground- water models in the Berkshire downs. At the regional scale, two conceptualizations of aquifer transmissivity, a zone-based approach and an interpolated transmissivity field approach, were implemented...

Assessing the economic and environmental value of carbon capture and utilisation in the UK

A Hankin, G Guillen Gosalbez, G Kelsall, N Mac Dowell, N Shah, S Weider & K Brophy
• As a signatory to the 2015 Paris Climate Change Agreement, the UK has committed to an ambitious transformation of its economy. • Decarbonisation of the UK’s economy must be a priority, but carbon-based fuels and platform chemicals will remain important to the global economy; their production from captured carbon dioxide and renewable energy can support this industrial need. • In this Briefing Paper, we report on results of a systematic procedure developed to assess...

Assessing the economic and environmental value of carbon capture and utilisation in the UK

A Hankin, G Guillen Gosalbez, G Kelsall, N Mac Dowell, N Shah, S Weider & K Brophy
• As a signatory to the 2015 Paris Climate Change Agreement, the UK has committed to an ambitious transformation of its economy. • Decarbonisation of the UK’s economy must be a priority, but carbon-based fuels and platform chemicals will remain important to the global economy; their production from captured carbon dioxide and renewable energy can support this industrial need. • In this Briefing Paper, we report on results of a systematic procedure developed to assess...

Imperial College London, 2018/19 RCUK open access compliance report

D Phillips, R Harrison, S Agunbiade, I McArdle & J Murtagh
This is the annual report to RCUK which records open access article processing charges paid from Imperial's Research Councils UK (RCUK) open access budget between 1 April 2018 and 31 March 2019, along with Imperial's overall compliance with the RCUK open access policy. The report was presented to UK Research and Innovation (UKRI) in May 2018. Please note that the compliance percentage was calculated based on a sample of some 2K College outputs that acknowledge...

The case for investment in technology to manage the global costs of dementia

J Barlow, M Knapp, A Comas-Herrera, J Damant, P Freddolino, K Hamblin, B Hu, K Lorenz, M Perkins, A Rehill, R Wittenberg & J Woolham
Worldwide growth in the number of people living with dementia will continue over the coming decades and is already putting pressure on health and care systems, both formal and informal, and on costs, both public and private. One response could be to make greater use of digital and other technologies to try to improve outcomes and contain costs. We were commissioned to examine the economic case for accelerated investment in technology that could, over time,...

Studies of the nonlinear response of stainless steel structures

Marios Theofanous
Current design guidance on stainless steel structures is largely based on assumed analogies with carbon steel, thereby neglecting stainless steels* actual material behaviour in favour of simplicity. However, its high initial cost warrants the development of improved design guidance which is rational, safe, efficient and in accordance with the actual nonlinear material behaviour. Within the current research project, all reported test data on stainless steel cross- sections (beams and stub columns) have been gathered and...

Studies on resistance and overwintering in hop powdery mildew (Sphaerotheca humuli (DC) Burr.)

Amarasiri De Silva Liyanage
The development of S. humuli on hop leaves was analysed with eight isolates, collected from various regions, and with several cultivara/ seedling hops containing either no resistance genes or one or more of three known major genes for resistance. Three mechanisms of resistance were discovered. (1) Controlled by gene I1, in which epidermal cells reacted hypersensitively immediately after penetration; haustoria were degenerated allowing no colony development. Originally this reaction occurred under natural conditions at Wye...

Climate change and challenges for conservation

I Prentice, M Dickenson & G Mace

Biosphere feedbacks and climate change

I Prentice, S Williams & P Friedlingstein

What is meant by ‘balancing sources and sinks of greenhouse gases’ to limit global temperature rise?

R Thomas, H Graven, B Hoskins & I Prentice
In an effort to limit global temperature rise to well below 2˚C, the COP21 Paris Agreement stipulates that a ‘balance’ between anthropogenic (man-made) sources and sinks of greenhouse gases must be reached by 2050-2100. An overall greenhouse gas ‘balance’ must consider individual gases in terms of how strongly they absorb solar infrared radiation, their concentration in the atmosphere, and their lifetime in the atmosphere. • Long-lived greenhouse gases, including carbon dioxide (CO2), accumulate in the...

Soil water flow processes : a critical evaluation using numerical simulations and lysimeter data

Joel Avruch Goldenfum
Physically-based soil water flow models generally use approaches based on Darcy's law and Richards' equation, and, although Darcy's law is itself an empirical approximation, such models have been well proven for ideal soils. Failures of Richards' equation to describe unsaturated water movement, however, are also reported. Anomalies have been attributed to the presence of a system of large, continuous, surface-connected pores in the soil, here referred to as macropores. Also, other phenomena, such as hysteresis...

Investigation of the cutting process in sandstones with blunt PDC cutters

Almenara Chau Jose Raimundo
The forces acting on the tools when cutting rock are not only important for the design of the cutters but also because they can be utilized to characterize the rock being cut. To understand these forces, it is necessary to have a good insight into the mechanisms that govern the failure of the rock. This thesis reports on studies of the cutting process with blunt — Polycrystalline Diamond Compact (PDC) — cutters. It presents a...

Experiences and lessons in managing water from Cape Town

R Parks, M Mclaren, R Toumi & U Rivett
Water shortages will become more common in cities around the world during the 21st century due to climate change.• Cape Town, South Africa experienced an especially severe drought in 2017-2018 after several years of low rainfall. This drought prompted an estimate of Day Zero, when freshwater reservoir levels supplying the city would fall below 13.5% of capacity and the majority of the municipal water network would be shut down.• In response to this crisis, the...

Assessment of Energy Centres in Brazil

A Strapasson, D Ferreira, HKDM Costa & JOP Pinto
HEADLINES: • The authors advise the British Embassy to create a Brazil-UK Energy Centre, with legitimacy, independence, and financial sustainability, involving leading stakeholders from the energy sector and academia. • This project identified 419 relevant stakeholders for the purpose of creating an integrated energy centre in Brazil, being 175 energy companies, 86 associations, 117 research and development institutions, and 41 governmental bodies. • 80 representative stakeholders were contacted and interviewed for this project through in-person...

Health outcomes in Undernutrition: the role of Nutrients, Gut dysfunction and the gut microbiome (HUNGer)

H Consortium, L Drake, G Frost, E Holmes, A Lett, K Maitland, J Marchesi, J Swann, Thompson, A Thompson & K Walsh
The HUNGer consortium is comprised of a multi-disciplinary, multi-national consortium of world leading researchers, with expertise in physiology and nutrition, through to clinical research, public health and agriculture in LMIC settings. The HUNGer consortium was awarded the MRC Confidence in Global Nutrition and Health award in 2018. The HUNGer consortium is developing a programme of work that will directly address United Nations Sustainable Development Goal 2 (SDG-2): End hunger, achieve food security and improve nutrition,...

Global Warming of 1.5oC

R Slade

A Tutorial Survey on Multimodal Deep Learning

D Coelho De Castro

An extension of UKRR into low-use monographs: does appetite exist?

T Stubbs

Land Use Change and the European Biofuels Policy: The expansion of oilseed feedstocks on lands with high carbon stocks

A Strapasson, J Falcão, T Rossberg, G Buss & J Woods

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