This dataset comprises cast reconstructions of brain cavity space in 60 extant avian species, derived from X-ray micro computed-tomography scan image stacks. Each reconstruction was made using Materialise Mimics 14.11 to create volumetric models (brain cavity casts) that were then transformed into the polygon mesh stereolithograph (STL) files archived here. Brain cavity cast models are in most cases accompanied by casts of main vascular features (e.g., carotid arteries) and the olfactory nerves (CN I). A...
The calculated optical rotatory dispersion for one atropisomer of (S)-Streptorubin
Rates of colon cancer are much higher in African Americans (65:100,000) than in rural South Africans (<5:100,000). The higher rates are associated with higher animal protein and fat, and lower fibre consumption, higher colonic secondary bile acids, lower colonic short-chain fatty acid quantities and higher mucosal proliferative biomarkers of cancer risk in otherwise healthy middle-aged volunteers. Here we investigate further the role of fat and fibre in this association. We performed 2-week food exchanges in...
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Atropisomerism in Taxol intermediates
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Data from: Epidemiological interactions between urogenital and intestinal human schistosomiasis in the context of praziquantel treatment across three West African countriesSarah C. L. Knowles, Bonnie L. Webster, Amadou Garba, Moussa Sacko, Oumar T. Diaw, Alan Fenwick, David Rollinson & Joanne P. Webster
Background: In many parts of sub-Saharan Africa, urogenital and intestinal schistosomiasis co-occur, and mixed species infections containing both Schistosoma haematobium and S. mansoni can be common. During co-infection, interactions between these two species are possible, yet the extent to which such interactions influence disease dynamics or the outcome of control efforts remains poorly understood. Methodology/Principal Findings: Here we analyse epidemiological data from three West African countries co-endemic for urogenital and intestinal schistosomiasis (Senegal, Niger and...
Data from: Redesigning the ‘choice architecture’ of hospital prescription charts: a mixed methods study incorporating in-situ simulationDominic King, Ali Jabbar, Esmita Charani, Colin Bicknell, Zhe Wu, Gavin Miller, Mark Gilchrist, Ivo Vlaev, Bryony Dean Franklin & Ara Darzi
Objectives: To incorporate behavioural insights into the user-centred design of an inpatient prescription chart (Imperial Drug Chart Evaluation and Adoption Study, IDEAS chart) and to determine whether changes in the content and design of prescription charts could influence prescribing behaviour and reduce prescribing errors. Design: A mixed-methods approach was taken in the development phase of the project; in situ simulation was used to evaluate the effectiveness of the newly developed IDEAS prescription chart. Setting: A...
Data from: Parasites in bloom: flowers aid dispersal and transmission of pollinator parasites within and between bee speciesPeter Graystock, Dave Goulson & William O. H. Hughes
The dispersal of parasites is critical for epidemiology, and the interspecific vectoring of parasites when species share resources may play an underappreciated role in parasite dispersal. One of the best examples of such a situation is the shared use of flowers by pollinators, but the importance of flowers and interspecific vectoring in the dispersal of pollinator parasites is poorly understood and frequently overlooked. Here, we use an experimental approach to show that during even short...
Data from: Liverworts to the rescue: an investigation of their efficacy as mycorrhizal inoculum for vascular plantsJill Kowal, Silvia Pressel, Jeffrey G. Duckett & Martin I. Bidartondo
Pezoloma ericae (D.J. Read) Baral, a widespread mycorrhizal fungus of plants in the Ericales, is known to form intracellular associations with several families of leafy liverworts (Schistochilaceae, Lepidoziaceae, Cephaloziaceae, Cephaloziellaceae) in vitro. The ecological significance of this link between vascular and non-vascular plants is unknown. Fungal symbionts were isolated from rhizoids of the leafy liverworts Cephalozia connivens (Dicks.) Lindb. and C. bicuspidata (L.) Dum. (Cephaloziaceae), as well as from the hair roots of two dominant...
Recombination enhances the adaptive potential of organisms by allowing genetic variants to be tested on multiple genomic backgrounds. Its distribution in the genome can provide insight into the evolutionary forces that underlie traits such as the emergence of pathogenicity. Here we examined landscapes of realized homologous recombination of 500 genomes from ten bacterial species, and found all species have ‘hot’ regions with elevated rates relative to the genome average. We examined the size, gene content...
Data from: Immune response and insulin signalling alter mosquito feeding behaviour to enhance malaria transmission potentialJose E. Pietri, Lauren J. Cator, Courtney C. Murdock, Johanna R. Ohm, Edwin E. Lews, Andrew F. Read, Shirley Luckhart & Matthew B. Thomas
Malaria parasites alter mosquito feeding behaviour in a way that enhances parasite transmission. This is widely considered a prime example of manipulation of host behaviour to increase onward transmission, but transient immune challenge in the absence of parasites can induce the same behavioural phenotype. Here, we show that alterations in feeding behaviour depend on the timing and dose of immune challenge relative to blood ingestion and that these changes are functionally linked to changes in...
Data from: Bacterial cooperation causes systematic errors in pathogen risk assessment due to the failure of the independent action hypothesisDaniel M. Cornforth, Andrew Matthews, Sam P. Brown & Ben Raymond
The Independent Action Hypothesis (IAH) states that pathogenic individuals (cells, spores, virus particles etc.) behave independently of each other, so that each has an independent probability of causing systemic infection or death. The IAH is not just of basic scientific interest; it forms the basis of our current estimates of infectious disease risk in humans. Despite the important role of the IAH in managing disease interventions for food and water-borne pathogens, experimental support for the...
Imperial College London79
University of Oxford6
Natural History Museum3
University of Birmingham2
Institut National de Recherche en Santé Publique1
VU University Amsterdam1
London School of Hygiene & Tropical Medicine1
University of Sussex1
The University of Texas at Austin1
National Museums Scotland1