1,650 Works

Xi_Product_1 (opt freq) error

Bethan Coulson
Gaussian Calculation

IRC_G_SO2py_1 (IRC)

Bethan Coulson
Gaussian Calculation

Bromine_Tosyl_isoTS_1 (opt ts freq)

Bethan Coulson
Gaussian Calculation

concerted opening of protonated epoxide cation by methanol saddle=1

Henry Rzepa
Gaussian Calculation

12-epoxide product

Henry Rzepa
Gaussian Calculation

IRC_Cubane_OMe_1 (IRC)

Bethan Coulson
Gaussian Calculation

Bromine_Tosyl_isoTS_2 (opt ts freq)

Bethan Coulson
Gaussian Calculation

Cubane_OMe_Ph_1 (opt ts freq)

Bethan Coulson
Gaussian Calculation

Data from: Divergent evolution peaks under intermediate population bottlenecks during bacterial experimental evolution

Tom Vogwill, Robyn L. Phillips, Danna R. Gifford & R. Craig MacLean
There is growing evidence that parallel molecular evolution is common, but its causes remain poorly understood. Demographic parameters such as population bottlenecks are predicted to be major determinants of parallelism. Here, we test the hypothesis that bottleneck intensity shapes parallel evolution by elucidating the genomic basis of adaptation to antibiotic-supplemented media in hundreds of populations of the bacterium Pseudomonas fluorescens Pf0-1. As expected, bottlenecking decreased the rate of phenotypic and molecular adaptation. Surprisingly, bottlenecking had...

Data from: Detecting evolutionarily significant units above the species level using the Generalized Mixed Yule Coalescent method

Aelys M. Humphreys, Catarina Rydin, Knud A. Jønsson, David Alsop, Leah M. Callender-Crowe & Timothy G. Barraclough
1. There is renewed interest in inferring evolutionary history by modelling diversification rates using phylogenies. Understanding the performance of the methods used under different scenarios is essential for assessing empirical results. Recently we introduced a new approach for analysing broadscale diversity patterns, using the Generalized Mixed Yule Coalescent (GMYC) method to test for the existence of evolutionarily significant units above the species (higher ESUs). This approach focuses on identifying clades as well as estimating rates...

Data from: Patterns of mammalian population decline inform conservation action

Martina M. I. Di Fonzo, Ben Collen, Alienor L. M. Chauvenet & Georgina M. Mace
1. Evaluations of wildlife population dynamics have the potential to convey valuable information on the type of pressure affecting a population and could help predict future changes in the population's trajectory. Greater understanding of different patterns of population declines could provide a useful mechanism for assessing decline severity in the wild and identifying those populations that are more likely to exhibit severe declines. 2. We identified 93 incidences of decline within 75 populations of mammalian...

Data from: Almost a spider: a 305-million-year-old fossil arachnid and spider origins

Russell J. Garwood, Jason A. Dunlop, Paul A. Selden, Alan R. T. Spencer, Robert C. Atwood, Nghia T. Vo & Michael Drakopoulos
Spiders are an important animal group, with a long history. Details of their origins remain limited, with little knowledge of their stem group, and no insights into the sequence of character acquisition during spider evolution. We describe a new fossil arachnid, Idmonarachne brasieri gen. et sp. nov. from the late Carboniferous (Stephanian, ca. 305–299 Ma) of Montceau-les-Mines, France. It is three-dimensionally preserved within a siderite concretion, allowing both laboratory- and synchrotron-based phase-contrast computed tomography (CT)...

Data from: Variation in relapse frequency and the transmission potential of Plasmodium vivax malaria

Michael T. White, George Shirreff, Stephan Karl, Azra C. Ghani & Ivo Mueller
There is substantial variation in the relapse frequency of Plasmodium vivax malaria, with fast relapsing strains in tropical areas, and slow relapsing strains in temperate areas with seasonal transmission. We hypothesise that much of the phenotypic diversity in P. vivax relapses arises from selection of relapse frequency to optimise transmission potential in a given environment, in a process similar to the virulence trade-off hypothesis. We develop mathematical models of P. vivax transmission and calculate the...

blog

Henry Rzepa
Portal project

Data from: A large fraction of HLA class I ligands are proteasome-generated spliced peptides

Juliane Liepe, Fabio Marino, John Sidney, Anita Jeko, Daniel E. Bunting, Alessandro Sette, Peter M. Kloetzel, Michael P. H. Stumpf, Albert J. R. Heck & Michele Mishto
The proteasome generates the epitopes presented on human leukocyte antigen (HLA) class I molecules that elicit CD8+ T cell responses. Reports of proteasome-generated spliced epitopes exist, but they have been regarded as rare events. Here, however, we show that the proteasome-generated spliced peptide pool accounts for one-third of the entire HLA class I immunopeptidome in terms of diversity and one-fourth in terms of abundance. This pool also represents a unique set of antigens, possessing particular...

High-resolution satellite-gauge merged precipitation climatologies of the tropical Andes

B. Manz, W. Buytaert, Z. Zulkafli, W. Lavado, B. Willems, A. Robles L. & J.-P. Rodríguez Sánchez
A set of 130 digital precipitation maps of the tropical Andes, covering Colombia, Ecuador and Peru at a 5km resolution. The maps represent different realizations of mean precipitation totals of the period 1981-2010 using different satellite-gauge merging methods. The work draws on a large database of 723 rain gauges and the full 5km Tropical Rainfall Measuring Mission (TRMM) Precipitation Radar (TPR) record from 1998 to 2014. Each map is approximately 1MB

Xiii_TS_1 (opt modred)

Bethan Coulson
Gaussian Calculation

trimethyloxonium + Br(-) TS Def2-TZVPPD

Henry Rzepa
Gaussian Calculation

Ea_Product_2 (opt freq)

Bethan Coulson
Gaussian Calculation

x-ray conformation methanol TS Def2-TZVPPD BF4 ion pair, bottom face, NBO

Henry Rzepa
Gaussian Calculation

Cubane_iso3 (opt ts freq)

Bethan Coulson
Gaussian Calculation

Cubane_Product_1iso (opt freq)

Bethan Coulson
Gaussian Calculation

Desilylation using sodium acetate,to 5-coord reactant

Henry Rzepa
Gaussian Calculation

Sheppards proposal, O replacing bridging N scan O...B formation IRC derived reactant

Henry Rzepa
Gaussian Calculation

Conf2, wB97XD/Def2-TZVPP + CHCl3, VCD NMR

Henry Rzepa
Gaussian Calculation

Registration Year

  • 2016
    1,650

Resource Types

  • Dataset
    1,595
  • Collection
    55

Affiliations

  • Imperial College London
    1,650
  • University of Oxford
    6
  • Royal Botanic Gardens
    2
  • University of Groningen
    2
  • University of Gothenburg
    2
  • University of Manchester
    2
  • French National Centre for Scientific Research
    2
  • University College London
    2
  • Museo Nacional de Ciencias Naturales
    2
  • Zoological Society of London
    2