526 Works

Data from: Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk

Claire R. Quilter, Wendy N. Cooper, Kerry M. Cliffe, Benjamin M. Skinner, Philippa M. Prentice, LaTasha Nelson, Julien Bauer, Ken K. Ong, Constância Miguel, William L. Lowe, Nabeel A. Affara & David B. Dunger
Size at birth, postnatal weight gain, and adult risk for type 2 diabetes may reflect environmental exposures during developmental plasticity and may be mediated by epigenetics. Both low birth weight (BW), as a marker of fetal growth restraint, and high birth weight (BW), especially after gestational diabetes mellitus (GDM), have been linked to increased risk of adult type 2 diabetes. We assessed DNA methylation patterns using a bead chip in cord blood samples from infants...

Data from: Evf2 lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling

Ivelisse Cajigas, David E. Leib, Jesse Cochrane, Hao Luo, Kelsey R. Swyter, Sean Chen, Brain S. Clark, James Thompson, , Robert E. Kingston & Jhumku D. Kohtz
Transcription-regulating long non-coding RNAs (lncRNAs) have the potential to control the site-specific expression of thousands of target genes. Previously, we showed that Evf2, the first described ultraconserved lncRNA, increases the association of transcriptional activators (DLX homeodomain proteins) with key DNA enhancers but represses gene expression. In this report, mass spectrometry shows that the Evf2-DLX1 ribonucleoprotein (RNP) contains the SWI/SNF-related chromatin remodelers Brahma-related gene 1 (BRG1, SMARCA4) and Brahma-associated factor (BAF170, SMARCC2) in the developing mouse...

Data from: Adaptation to random and systematic errors: Comparison of amputee and non-amputee control interfaces with varying levels of process noise

Reva E. Johnson, Konrad P. Kording, Levi J. Hargrove & Jonathon W. Sensinger
The objective of this study was to understand how people adapt to errors when using a myoelectric control interface. We compared adaptation across 1) non-amputee subjects using joint angle, joint torque, and myoelectric control interfaces, and 2) amputee subjects using myoelectric control interfaces with residual and intact limbs (five total control interface conditions). We measured trial-by-trial adaptation to self-generated errors and random perturbations during a virtual, single degree-of-freedom task with two levels of feedback uncertainty,...

Data from: An ab initio electronic transport database for inorganic materials

Francesco Ricci, Wei Chen, Umut Aydemir, Jeffrey Snyder, Gian-Marco Rignanese, Anubhav Jain & Geoffroy Hautier
Electronic transport in materials is governed by a series of tensorial properties such as conductivity, Seebeck coefficient, and effective mass. These quantities are paramount to the understanding of materials in many fields from thermoelectrics to electronics and photovoltaics. Transport properties can be calculated from a material’s band structure using the Boltzmann transport theory framework. We present here the largest computational database of electronic transport properties based on a large set of 48,000 materials originating from...

Seed size and capitulum position drive germination and dormancy responses to projected warming for the threatened dune endemic Cirsium pitcheri (Asteraceae)

Finote Gijsman & Pati Vitt
Among coastal plant species at risk from rapid environmental changes is the North American Great Lakes dune endemic Cirsium pitcheri. Despite being listed as federally threatened, little is known about how C. pitcheri seed attributes influence germination and dormancy-break patterns in the context of climate change. Following a previous work where we found differences in the number and weight of C. pitcheri seeds among capitulum positions and study sites, here we examine the effects of...

Resource competition shapes biological rhythms and promotes temporal niche differentiation in a community simulation

Vance Gao, Sara Morley-Fletcher, Stefania Maccari, Martha Vitaterna & Fred Turek
This is the code and dataset for the article entitled "Resource competition shapes biological rhythms and promotes temporal niche differentiation in a community simulation," in the journal Ecology and Evolution. Competition for resources often contributes strongly to defining an organism’s ecological niche. Endogenous biological rhythms are important adaptations to the temporal dimension of niches, but how other organisms influence such temporal niches have not been much studied, and the role of competition in particular has...

Supplemental materials for: Implementation and evaluation of an objective structured clinical examination (OSCE) tool for neurology post-graduate trainees in Lusaka, Zambia

Rebecca DiBiase
Introduction: Despite the high burden of neurologic disease in Zambia, a low-middle income sub-Saharan African country of 18 million people, there are currently no Zambian neurologists. We established the first neurology residency program in Zambia at the University of Zambia School of Medicine and the University Teaching Hospital in Lusaka. We evaluated the feasibility and effectiveness of a modified Objective Structured Clinical Examination (OSCE) to assess clinical skills. Program Description: The neurology training program began...

Data from: Absolute axial growth and trunk segmentation in the early Cambrian trilobite Oryctocarella duyunensis

Tao Dia, Nigel Hughes, Xingliang Zhang, Giuseppe Fusco & Nigel Hughes
A short stratigraphic interval near Bulin in western Hunan (China) yields multiple specimens of the ~514 Ma old oryctocarine trilobite Oryctocarella duyunensis. Size data obtained from these specimens indicates that, from meraspid degree 1 onwards, degrees represent successive instars. Meraspid growth persisted until a terminal stage was reached, providing the first example of determinate growth in trilobites and, notably, in an early Cambrian species. The sample contains three varieties of such terminal stages, recognized as...

Variations in the Intensity and Spatial Extent of Tropical Cyclone Precipitation

Danielle Touma, Samantha Stevenson, Suzana Camargo, Daniel Horton & Noah Diffenbaugh
The intensity and spatial extent of tropical cyclone precipitation (TCP) often shapes the risk posed by landfalling storms. Here we provide a comprehensive climatology of landfalling TCP characteristics as a function of tropical cyclone strength, using daily precipitation station data and Atlantic US landfalling tropical cyclone tracks from 1900-2017. We analyze the intensity and spatial extent of ≥ 1 mm/day TCP (Z1) and ≥ 50 mm/day TCP (Z50). We show that the highest median intensity...

Paralogs and off-target sequences improve phylogenetic resolution in a densely-sampled study of the breadfruit genus (Artocarpus, Moraceae)

Elliot Gardner, Matthew Johnson, Joan Pereira, Aida Shafreena Ahmad Puad, Deby Arifiani, Sahromi Sahromi, Norman Wickett & Nyree Zerega
We present a 517-gene phylogenetic framework for the breadfruit genus Artocarpus (ca. 70 spp., Moraceae), making use of silica-dried leaves from recent fieldwork and herbarium specimens (some up to 106 years old) to achieve 96% taxon sampling. We explore issues relating to assembly, paralogous loci, partitions, and analysis method to reconstruct a phylogeny that is robust to variation in data and available tools. While codon partitioning did not result in any substantial topological differences, the...

Neurological deterioration in patients with acute ischemic stroke or transient ischemic attack

Tai Hwan Park, Jeong-Kon Lee, Moo-Seok Park, Sang-Soon Park, Keun-Sik Hong, Wi-Sun Ryu, Dong-Eog Kim, Man Seok Park, Kang-Ho Choi, Joon-Tae Kim, Jihoon Kang, Beom Joon Kim, Moon-Ku Han, Jun Lee, Jae-Kwan Cha, Dae-Hyun Kim, Jae Guk Kim, Soo Joo Lee, Yong-Jin Cho, Jee-Hyun Kwon, Dong-Ick Shin, Min-Ju Yeo, Sung Il Sohn, Jeong-Ho Hong, Ji Sung Lee … & Hee-Joon Bae
Objective: To improve epidemiological knowledge of neurological deterioration (ND) in patients with acute ischemic stroke (AIS). Methods: In this prospective observational study, we captured ND prospectively in 29,446 AIS patients admitted to 15 hospitals in Korea within 7 days of stroke onset. ND was defined as an increase in National Institutes of Health Stroke Scale (NIHSS) score ≥2 (total), or ≥1 (motor or consciousness), or any new neurological symptoms. Change of incidence rate after stroke...

Plasmodium infection is associated with cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein

Sarah Lapidus, Feimei Liu, Arnau Casanovas-Massana, Yile Dai, John D. Huck, Carolina Lucas, Jon Klein, Renata B. Filler, Madison S. Strine, Mouhamad Sy, Awa B. Deme, Aida S. Badiane, Baba Dieye, Ibrahima Mbaye Ndiaye, Younous Diedhiou, Amadou Moctar Mbaye, Cheikh Tidiane Diagne, Inés Vigan-Womas, Alassane Mbengue, Bacary D. Sadio, Moussa M. Diagne, Adam J. Moore, Khadidiatou Mangou, Fatoumata Diallo, Seynabou D. Sene … & Amy K. Bei
Sero-surveillance can monitor and project disease burden and risk. However, SARS-CoV-2 antibody test results can produce false positive results, limiting their efficacy as a sero-surveillance tool to estimate population-level SARS-CoV-2 exposure. False positive SARS-CoV-2 antibody results have been associated with malaria exposure, and understanding this association is essential to interpret sero-surveillance results from malaria-endemic countries. Here, pre-pandemic samples from eight malaria endemic and non-endemic countries and four continents were tested by ELISA to measure SARS-CoV-2...

Emerging English Transitives over the Last Two Centuries

Liwen Hou & David Smith

Searching for Stellar Associations in Gaia DR2

Brolan Jennings, Jeff Andrews, Marcel Agüeros & Julio Chanamé

Socioeconomic impacts on Andean adolescents’ growth: variation between households, between communities, and over time

Virginia J. Vitzthum, Jonathan Thornburg & Thomas McDade
Background/Objectives We evaluated potential socioeconomic contributors to variation in Andean adolescents’ growth between households within a peri-urban community undergoing rapid demographic and economic change, between different community types (rural, peri-urban, urban), and over time. Because growth monitoring is widely used for assessing community needs and progress, we compared the prevalences of stunting, underweight, and overweight estimated by three different growth references. Results Alteños’ height averaged ∼0.8SD/∼0.6SD/∼2SDs greater than adolescents’ height in urban and rural communities...

A comprehensive update on CIDO: the community-based coronavirus infectious disease ontology

Yongqun He, Hong Yu, Anthony Huffman, Asiyah Yu Lin, Darren A. Natale, John Beverley, Ling Zheng, Yehoshua Perl, Zhigang Wang, Yingtong Liu, Edison Ong, Yang Wang, Philip Huang, Long Tran, Jinyang Du, Zalan Shah, Easheta Shah, Roshan Desai, Hsin-hui Huang, Yujia Tian, Eric Merrell, William D. Duncan, Sivaram Arabandi, Lynn M. Schriml, Jie Zheng … & Barry Smith
Abstract Background The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation,...

Additional file 2 of A comprehensive update on CIDO: the community-based coronavirus infectious disease ontology

Yongqun He, Hong Yu, Anthony Huffman, Asiyah Yu Lin, Darren A. Natale, John Beverley, Ling Zheng, Yehoshua Perl, Zhigang Wang, Yingtong Liu, Edison Ong, Yang Wang, Philip Huang, Long Tran, Jinyang Du, Zalan Shah, Easheta Shah, Roshan Desai, Hsin-hui Huang, Yujia Tian, Eric Merrell, William D. Duncan, Sivaram Arabandi, Lynn M. Schriml, Jie Zheng … & Barry Smith
Additional file 2: Supplemental Table 1. Resources used for our coronavirus disease-related data collection.

Additional file 2 of A comprehensive update on CIDO: the community-based coronavirus infectious disease ontology

Yongqun He, Hong Yu, Anthony Huffman, Asiyah Yu Lin, Darren A. Natale, John Beverley, Ling Zheng, Yehoshua Perl, Zhigang Wang, Yingtong Liu, Edison Ong, Yang Wang, Philip Huang, Long Tran, Jinyang Du, Zalan Shah, Easheta Shah, Roshan Desai, Hsin-hui Huang, Yujia Tian, Eric Merrell, William D. Duncan, Sivaram Arabandi, Lynn M. Schriml, Jie Zheng … & Barry Smith
Additional file 2: Supplemental Table 1. Resources used for our coronavirus disease-related data collection.

Additional file 1 of Sustainable deimplementation of continuous pulse oximetry monitoring in children hospitalized with bronchiolitis: study protocol for the Eliminating Monitor Overuse (EMO) type III effectiveness-deimplementation cluster-randomized trial

Christopher P. Bonafide, Rui Xiao, Amanda C. Schondelmeyer, Amy R. Pettit, Patrick W. Brady, Christopher P. Landrigan, Courtney Benjamin Wolk, Zuleyha Cidav, Halley Ruppel, Naveen Muthu, Nathaniel J. Williams, Enrique Schisterman, Canita R. Brent, Kimberly Albanowski & Rinad S. Beidas
Additional file 1. DSMB Charter, Version Dated September 14, 2021. Description: Charter outlining the roles, responsibilities, practices, and procedures of the EMO Trial Data and Safety Monitoring Board.

Additional file 4 of Sustainable deimplementation of continuous pulse oximetry monitoring in children hospitalized with bronchiolitis: study protocol for the Eliminating Monitor Overuse (EMO) type III effectiveness-deimplementation cluster-randomized trial

Christopher P. Bonafide, Rui Xiao, Amanda C. Schondelmeyer, Amy R. Pettit, Patrick W. Brady, Christopher P. Landrigan, Courtney Benjamin Wolk, Zuleyha Cidav, Halley Ruppel, Naveen Muthu, Nathaniel J. Williams, Enrique Schisterman, Canita R. Brent, Kimberly Albanowski & Rinad S. Beidas
Additional file 4. SPIRIT 2013 Checklist

Sustainable deimplementation of continuous pulse oximetry monitoring in children hospitalized with bronchiolitis: study protocol for the Eliminating Monitor Overuse (EMO) type III effectiveness-deimplementation cluster-randomized trial

Christopher P. Bonafide, Rui Xiao, Amanda C. Schondelmeyer, Amy R. Pettit, Patrick W. Brady, Christopher P. Landrigan, Courtney Benjamin Wolk, Zuleyha Cidav, Halley Ruppel, Naveen Muthu, Nathaniel J. Williams, Enrique Schisterman, Canita R. Brent, Kimberly Albanowski & Rinad S. Beidas
Abstract Background Methods of sustaining the deimplementation of overused medical practices (i.e., practices not supported by evidence) are understudied. In pediatric hospital medicine, continuous pulse oximetry monitoring of children with the common viral respiratory illness bronchiolitis is recommended only under specific circumstances. Three national guidelines discourage its use for children who are not receiving supplemental oxygen, but guideline-discordant practice (i.e., overuse) remains prevalent. A 6-hospital pilot of educational outreach with audit and feedback resulted in...

Additional file 2 of Sustainable deimplementation of continuous pulse oximetry monitoring in children hospitalized with bronchiolitis: study protocol for the Eliminating Monitor Overuse (EMO) type III effectiveness-deimplementation cluster-randomized trial

Christopher P. Bonafide, Rui Xiao, Amanda C. Schondelmeyer, Amy R. Pettit, Patrick W. Brady, Christopher P. Landrigan, Courtney Benjamin Wolk, Zuleyha Cidav, Halley Ruppel, Naveen Muthu, Nathaniel J. Williams, Enrique Schisterman, Canita R. Brent, Kimberly Albanowski & Rinad S. Beidas
Additional file 2. Dissemination plan for results of the EMO Trial. Description: Description of the plan for disseminating results and products of the EMO trial. This document was also submitted with the EMO Trial grant proposal.

Additional file 1 of Simplified regimen of combined low-dose rituximab for autoimmune encephalitis with neuronal surface antibodies

Ying Du, Chao Zhao, Juntong Liu, Chuan Li, Qi Yan, Lin Li, Yunfeng Hao, Dan Yao, Huaxing Si, Yingjun Zhao & Wei Zhang
Additional file 1: Table S1. Clinical improvements in rituximab cohort and control cohort

Additional file 10 of Quantitative analysis of transcriptome dynamics provides novel insights into developmental state transitions

Kristin Johnson, Simon Freedman, Rosemary Braun & Carole LaBonne
Additional file 10. Supplemental Table 1. List of all Monotonically Decreasing Genes with >25 Fold Decrease from Stage 9 to 13 and their average TPM across 3 biological replicates in all conditions.

Additional file 18 of Quantitative analysis of transcriptome dynamics provides novel insights into developmental state transitions

Kristin Johnson, Simon Freedman, Rosemary Braun & Carole LaBonne
Additional file 18. Supplemental Table 9. List of all genes from the venn diagrams of genes temporally differentially expressed in endoderm and mesoderm lineages corresponding with Fig. 5B.

Registration Year

  • 2022
    434
  • 2021
    33
  • 2020
    26
  • 2019
    15
  • 2018
    9
  • 2017
    3
  • 2016
    1
  • 2015
    3
  • 2014
    2

Resource Types

  • Text
    212
  • Dataset
    158
  • Collection
    103
  • Image
    44
  • Journal Article
    4
  • Other
    3
  • Audiovisual
    2

Affiliations

  • Northwestern University
    526
  • Sun Yat-sen University
    216
  • Zhejiang University
    200
  • First Affiliated Hospital of Soochow University
    198
  • Sichuan University
    194
  • Shanghai Jiao Tong University
    190
  • Nanjing Medical University
    190
  • Huazhong University of Science and Technology
    180
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    178
  • Wuhan University
    176