Additional file 2. MEDLINE draft search strategy.

Additional file 20. Supplemental Table 11. List of Genes from Venn Diagrams of Genes Temporally Differentially Expressed in mesoderm and epidermal lineages corresponding with Fig. 7C.

Additional file 20. Supplemental Table 11. List of Genes from Venn Diagrams of Genes Temporally Differentially Expressed in mesoderm and epidermal lineages corresponding with Fig. 7C.

Additional file 21. Supplemental Table 12. Lists of epidermal and mesoderm GO Terms and their over represented p value in genes differentially expressed between the epidermal and mesoderm lineages corresponding with supplemental figure 7B.

Word embedding, a high-dimensional (HD) numerical representation of words generated by machine learning models, has been used for different natural language processing tasks, for example, translation between two languages. Recently, there has been an increasing trend of transforming the HD embeddings into a latent space (e.g. via autoencoders) for further tasks, exploiting various merits the latent representations could bring. To preserve the embeddings’ quality, these works often map the embeddings into an even higher-dimensional latent...

Abstract Diffuse intrinsic pontine glioma (DIPG) is an aggressive incurable brainstem tumor that targets young children. Complete resection is not possible, and chemotherapy and radiotherapy are currently only palliative. This study aimed to identify potential therapeutic agents using a computational pipeline to perform an in silico screen for novel drugs. We then tested the identified drugs against a panel of patient-derived DIPG cell lines. Using a systematic computational approach with publicly available databases of gene...

Additional file 2: Figure S2. Comparative analyses of the sequencing depth (A) and allele frequency (B) between the matched alterations and specific alterations.

Additional file 4.

Abstract Background Successful practice of precision medicine in advanced lung cancers relies on therapeutic regimens tailored to individual molecular characteristics. The aim of this study was to investigate the accuracy of small specimens for molecular profiling using next-generation sequencing (NGS). Methods Genetic alternations, tumor mutational burden (TMB), status of microsatellite instability (MSI), and expression of programmed death ligand 1 (PD-L1) were compared side-by-side between the concurrently obtained core needle biopsy (CNB) and resection specimens in...

Additional file 1: Table S1. The ability of anti-oxidantstrains to remove various oxidants: differentconcentrations of hydrogen peroxide (0, 1.5, and 3 mM of H2O2).Planomicrobium-AX6 is an antioxidantstrain isolated from the Qaidam Basin; the model strain Escherichia coli was used as a negative control; Deinococcus radiodurans was used as apositive control. Table S2. Summary of the sequencing data of strain Planomicrobium-AX6. Table S3 Selected significantly differentially expressed genes (DEGs) for strainPlanomicrobium-AX6 when exposed for 4hr to...

Abstract Background The bacterial mechanisms responsible for hydrogen peroxide (H2O2) scavenging have been well-reported, yet little is known about how bacteria isolated from cold-environments respond to H2O2 stress. Therefore, we investigated the transcriptional profiling of the Planomicrobium strain AX6 strain isolated from the cold-desert ecosystem in the Qaidam Basin, Qinghai-Tibet Plateau, China, in response to H2O2 stress aiming to uncover the molecular mechanisms associated with H2O2 scavenging potential. Methods We investigated the H2O2-scavenging potential of...

Abstract Background The bacterial mechanisms responsible for hydrogen peroxide (H2O2) scavenging have been well-reported, yet little is known about how bacteria isolated from cold-environments respond to H2O2 stress. Therefore, we investigated the transcriptional profiling of the Planomicrobium strain AX6 strain isolated from the cold-desert ecosystem in the Qaidam Basin, Qinghai-Tibet Plateau, China, in response to H2O2 stress aiming to uncover the molecular mechanisms associated with H2O2 scavenging potential. Methods We investigated the H2O2-scavenging potential of...

Abstract Muscle size and composition (muscle volume and muscle fat infiltrate [MFI]) may provide insight into possible mechanisms underpinning chronic idiopathic neck pain, a common condition with no definitive underlying pathology. In individuals with chronic idiopathic neck pain > 3 months and age- and sex-matched asymptomatic controls, muscle volumes of levator scapulae, multifidus including semispinalis cervicis (MFSS), semispinalis capitis, splenius capitis including splenius cervicis (SCSC), sternocleidomastoid and longus colli from C3 through T1 were quantified...

Additional file 2: Supplemental file 2. The Risk of bias in the included retrospective cohort studies (by the Newcastle–Ottawa quality assessment tool).

Abstract Background Spontaneous rupture is a life-threatening complication of hepatocellular carcinoma (HCC). Recent trends in surgical treatments avoid emergency hepatectomy (EH) and favor emergency transarterial embolization (TAE) followed by delayed hepatectomy (DH). Still, there is debate on which is the better treatment option and whether delaying hepatectomy increases peritoneal metastasis. Aim To provide evidence-based references for the optimal management of patients with spontaneously ruptured HCC by comparing the outcomes of EH and DH. Methods Literature...

Abstract Background Gastric duplication cyst associated with ectopic pancreas is rare and we aimed to alert clinician to this congenital anomaly. Case presentation A 15-year-old girl presented with intermittent vomiting. Gastroscopy showed a submucosal tumor with an approximate diameter of 40 mm in the anterior wall of the gastric antrum. The lesion had a central umbilication and was diagnosed preliminarily as gastric ectopic pancreas with pseudocyst formation on the basis of its appearance. However, computed...

Additional file 1: Fig S1. The cystic portion’s cyst wall was lined by epithelium of gastric and surrounded by smooth muscle (hematoxylin and eosin [H&E] stain, ×10).

Objective/Research Question:This article examines the racial equity of transfer incentive policies by responding to the research question: How do students of differing races and ethnicities vary in their opportunity to benefit from transfer incentive policies?Methods:We utilized a mixed-methods approach, grounded in Critical Race Theory (CRT). This study included an analysis of state policies’ components and mechanisms to consider whether they are grounded in racially unjust assumptions. The critical policy analysis is combined with a QuantCrit...

Supplemental material, sj-docx-1-crw-10.1177_00915521221125826 for Racial Equity in Transfer Incentive Policies: A Critical Mixed Methods Analysis by Chrystal A. George Mwangi, Patricia Feraud-King, Ling Chen, Miguel Tejada, Caryn Brause, Kat J. Stephens, Jamina M. Scippio-McFadden, Jeffrey Edelstein and Ryan S. Wells in Community College Review

Additional file 3: Table S3. Prevalence estimates for Ascaris infection based on sub-groups according to different geographic and climate parameters, calculated using a random effects model. Table S4. Association between study variables and heterogeneity of Ascariasis prevalence estimates.

Additional file 4: Figure S1. Search strategy in databases. Figure S2. Random-effects meta-regression analyses of the prevalence of Ascaris infection in general population according to (A) a country's income level, showing a statistically significant downward trend in prevalence in countries with higher income levels; (B) human development index (HDI), showing a statistically significant downward trend in prevalence in countries with higher HDIs. Figure S3. Random-effects meta-regression analyses of the prevalence of Ascaris infection in the...

Additional file 4: Figure S1. Search strategy in databases. Figure S2. Random-effects meta-regression analyses of the prevalence of Ascaris infection in general population according to (A) a country's income level, showing a statistically significant downward trend in prevalence in countries with higher income levels; (B) human development index (HDI), showing a statistically significant downward trend in prevalence in countries with higher HDIs. Figure S3. Random-effects meta-regression analyses of the prevalence of Ascaris infection in the...

Abstract A novel recombinant SIRPα-Fc fusion protein, IMM01, was constructed and produced using an in-house developed CHO-K1 cell expression system, and the anti-tumor mechanism of IMM01 targeting the CD47-SIRPα pathway was explored. The phagocytosis and in vitro anti-tumor activity of IMM01 were evaluated by antibody-dependent cellular phagocytosis (ADCP), antibody-dependent cell-mediated cytotoxicity (ADCC), and complement-dependent cytotoxicity (CDC) assays. In vivo mouse tumor model studies were used to explore therapeutic efficacy as well as the mechanism of...

Supplementary materials to the article ' National survey on unplanned readmissions for diabetic kidney disease: Insight from a new paradigm of obesity'

Aeromonas caviae, an important food-borne pathogen, induces serious invasive infections and inflammation. The pro-inflammatory IL-1β functions against pathogenic infections and is elevated in various Aeromonas infection cases. However, the molecular mechanism of A. caviae-mediated IL-1β secretion remains unknown. In this study, mouse macrophages (PMs) were used to establish A. caviae infection model and multiple strategies were utilized to explore the mechanism of IL-1β secretion. IL-1β was elevated in A. caviae infected murine serum, PMs lysates...