Additional file 1: Supplemental file 1. The search formula for each database.

Additional file 1: Supplemental file 1. The search formula for each database.

Additional file 3: Table S3. Meta-signature derived from the two bulk RNAseq datasets.

Additional file 3: Supplemental Figure 3. Temporal DESeq UpSet Plots. (A-J) UpSet plots of Differentially Expressed Genes (A) increased between stages 9 and 10, (B) decreased between stages 9 and 10, (C) increased between stages 10 and 10.5, (D) decreased between stages 10 and 10.5, (E) increased between stages 10.5 and 11, (F) decreased between stages 10.5 and 11, (G) increased between stages 11 and 12, (H) decreased between stages 11 and 12, (I) increased...

Additional file 3: Supplemental Figure 3. Temporal DESeq UpSet Plots. (A-J) UpSet plots of Differentially Expressed Genes (A) increased between stages 9 and 10, (B) decreased between stages 9 and 10, (C) increased between stages 10 and 10.5, (D) decreased between stages 10 and 10.5, (E) increased between stages 10.5 and 11, (F) decreased between stages 10.5 and 11, (G) increased between stages 11 and 12, (H) decreased between stages 11 and 12, (I) increased...

Additional file 4: Supplemental Table 3. Protein Ontology representation of SARS-CoV-2 proteins. Comparative information in RefSeq and UniProtKB is also provided.

Abstract Background The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation,...

Additional file 5: Table S4. Top 20 hits of drugs identified by machine-learning aided drug repurposing pipeline in this study.

Additional file 6: Table S5. The list of altered genes with corresponding pathways.

Through the years, epinephrine has been the drug of choice for patients with cardiogenic shock. However, epinephrine was clinically inferior to norepinephrine in comparison studies because of the negative patient outcomes, which were statistically significant. These effects include type B lactic acidosis, tachycardia, increased myocardial oxygen demand, and arrhythmias.

Additional file 1: SupplementaryFigure 1. The top 10 cited countrys related to this field.

Additional file 3: Supplementarytable 1. The top 10 country and cited country in this field.

Additional file 5: Supplementary Table 3. The top 10 Keywordsrelated to this field.

Additional file 6: Supplementary Table 4. The top 10 institutions and cited institutions related to this field.

Human-induced biodiversity loss negatively affects ecosystem function, but the interactive effects of biodiversity change across trophic levels remain insufficiently understood. We sampled arboreal spiders and lepidopteran larvae across seasons in 2 years in a subtropical tree diversity experiment, and then disentangled the links between tree diversity and arthropod predator diversity by deconstructing the pathways among multiple components of diversity (taxonomic, phylogenetic and functional) with structural equation models. We found that herbivores were major mediators of...

Article full text The article associated with this page has been accepted for online publication and is in the final stages of production. The link to the full text will be made available on this page in the next few days. The above Video Abstract and Infographic represents the opinions of the [author/authors]. For a full list of declarations, including funding and author disclosure statements, and copyright information, please see the full text online. (see...

ObjectivesThis study evaluated the effect of implementing a hierarchical pharmaceutical service pattern based on the knowledge–attitude–practice (KAP) intervention theory on patients with systemic lupus erythematosus.MethodsEligible patients were randomly divided into an intervention or control group. Pharmaceutical service classification criteria were formulated and used to provide patients with differing levels of pharmaceutical services. The classification scores and KAP levels of patients before and at various time points after the intervention were analyzed. The rates of acute...

Supplemental material, sj-pdf-1-imr-10.1177_03000605231154749 for Implementation effect of a hierarchical pharmaceutical service pattern in patients with systemic lupus erythematosus by Yinhua Gong, Wei Wei, Wei Zhang, Qiang Han and Chunge Zhang in Journal of International Medical Research

There is no conclusive evidence comparing the efficacy of glucagon-like peptide 1 (GLP-1) receptor agonists to the other guidelines recommended pharmacotherapy for nonalcoholic fatty liver disease (NAFLD). Therefore, we aim to compare the effects of GLP-1 receptor agonists, pioglitazone and vitamin E in patients with NAFLD. We searched PubMed, Embase, Web of Science and Cochrane Library up to 11 April 2022. Randomized clinical trials (RCTs) comparing GLP-1 receptor agonists, pioglitazone and vitamin E against placebo...

Obtaining ideal gene delivery vectors is still a major goal in cancer gene therapy. CAMEL, a short hybrid antimicrobial peptide, can kill cancer cells by membrane lysis. In this study, we constructed a series of non-viral vectors by attaching fatty acids with different chain lengths to the N-terminus of CAMEL. Our results showed that the cellular uptake and transfection efficiency of acyl-CAMEL started to significantly increase from a chain length of 12 carbons. C18-CAMEL was...

Costs for obstetrical care may be increasing for both patients and insurers. To examine predictors of and trends in the cost of medical care during pregnancy. We performed a study of pregnancies from 2009 to 2019 covered by commercial insurance resulting in term, singleton delivery hospitalizations and included in the MarketScan database. The analysis categorized pregnancies based on whether delivery occurred via cesarean versus vaginal delivery and whether pre-gestational diabetes or chronic hypertension was present....

Qingre Huoxue (QRHX) decoction, a traditional Chinese medicine, has been widely used to prevent and treat myocardial infarction (MI). This study elucidates the possible mechanisms of QRHX in preventing or treating MI in a rat model. The chemical constituents of QRHX were identified by UPLC-MS. Sprague-Dawley rats were randomly divided into the Sham (normal saline), Model (normal saline), QRHX-L, QRHX-M and QRHX-H group (n = 10 per group). QRHX decoction was administered by gavage to...

MicroRNAs (miRNAs) have vastly expanded our view of RNA world in intracellular signal regulating networks. Here, we functionally characterized a normally highly expressed miRNA, miR-30a-5p (MIMAT0000087), which exhibits downregulated expression profiles in prostate cancer samples. MiR-30a-5p knockdown and overexpression in PC-3 cell line alters cell proliferation supporting a tumour suppressor role. We also discovered that PCLAF is the direct target of miR-30a-5p. Notably, PC-3 cell proliferation is inhibited by miR-30a-5p/PCLAF axis. miR-30a-5p represents a novel...

MicroRNAs (miRNAs) have vastly expanded our view of RNA world in intracellular signal regulating networks. Here, we functionally characterized a normally highly expressed miRNA, miR-30a-5p (MIMAT0000087), which exhibits downregulated expression profiles in prostate cancer samples. MiR-30a-5p knockdown and overexpression in PC-3 cell line alters cell proliferation supporting a tumour suppressor role. We also discovered that PCLAF is the direct target of miR-30a-5p. Notably, PC-3 cell proliferation is inhibited by miR-30a-5p/PCLAF axis. miR-30a-5p represents a novel...

β-galactosidase catalyzes lactose hydrolysis and transfers reactions to produce prebiotics such as galacto-oligosaccharides (GOS) with potential applications in the food industry and pharmaceuticals. However, there is still a need for improved transgalactosylation activity of β-galactosidases and reaction conditions of GOS production in order to maximize GOS output and reduce production costs. In this study, a β-galactosidase gene, galA, from Bacillus circulans was expressed in Pichia pastoris, which not only hydrolyzed lactose but also had strong...