Objective: To improve epidemiological knowledge of neurological deterioration (ND) in patients with acute ischemic stroke (AIS). Methods: In this prospective observational study, we captured ND prospectively in 29,446 AIS patients admitted to 15 hospitals in Korea within 7 days of stroke onset. ND was defined as an increase in National Institutes of Health Stroke Scale (NIHSS) score ≥2 (total), or ≥1 (motor or consciousness), or any new neurological symptoms. Change of incidence rate after stroke...
Paralogs and off-target sequences improve phylogenetic resolution in a densely-sampled study of the breadfruit genus (Artocarpus, Moraceae)Elliot Gardner, Matthew Johnson, Joan Pereira, Aida Shafreena Ahmad Puad, Deby Arifiani, Sahromi Sahromi, Norman Wickett & Nyree Zerega
We present a 517-gene phylogenetic framework for the breadfruit genus Artocarpus (ca. 70 spp., Moraceae), making use of silica-dried leaves from recent fieldwork and herbarium specimens (some up to 106 years old) to achieve 96% taxon sampling. We explore issues relating to assembly, paralogous loci, partitions, and analysis method to reconstruct a phylogeny that is robust to variation in data and available tools. While codon partitioning did not result in any substantial topological differences, the...
Plasmodium infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike proteinSarah Lapidus, Feimei Liu, Arnau Casanovas-Massana, Yile Dai, John D. Huck, Carolina Lucas, Jon Klein, Renata B. Filler, Madison S. Strine, Mouhamad Sy, Awa B. Deme, Aida S. Badiane, Baba Dieye, Ibrahima Mbaye Ndiaye, Younous Diedhiou, Amadou Moctar Mbaye, Cheikh Tidiane Diagne, Inés Vigan-Womas, Alassane Mbengue, Bacary D. Sadio, Moussa M. Diagne, Adam J. Moore, Khadidiatou Mangou, Fatoumata Diallo, Seynabou D. Sene … & Amy K. Bei
Individuals with acute malaria infection generated high levels of antibodies that cross-react with the SARS-CoV-2 Spike protein. Cross-reactive antibodies specifically recognized the sialic acid moiety on N-linked glycans of the Spike protein and do not neutralize in vitro SARS-CoV-2. Sero-surveillance is critical for monitoring and projecting disease burden and risk during the pandemic; however, routine use of Spike protein-based assays may overestimate SARS-CoV-2 exposure and population-level immunity in malaria-endemic countries.
Development and application of a hybrid implementation research framework to understand success in reducing under-5 mortality in RwandaLisa Hirschhorn, Miriam Frisch, Jovial Thomas Ntawukuriryayo, Amelia VanderZanden, Kateri Donahoe, Kedest Mathewos, Felix Sayinzoga & Agnes Binagwaho
Exemplars U5M Interview Guide: This is an example of the semi-structured interview guide used for key informant interviews described in the article, "Development and application of a hybrid implementation research framework to understand success in reducing under-5 mortality in Rwanda." Extended data (supplemental) tables and figures: These are the supplemental tables and figures to accompany the article, "Development and application of a hybrid implementation research framework to understand success in reducing under-5 mortality in Rwanda."...
Keratin intermediate filaments are an essential and major component of the cytoskeleton in epithelial cells. They form a stable yet dynamic filamentous network extending from the nucleus to the cell periphery, which provides resistance to mechanical stresses. Mutations in keratin genes are related to a variety of epithelial tissue diseases. Despite their importance, the molecular structure of keratin filaments remains largely unknown. In this study, we analyzed the structure of keratin 5/keratin 14 filaments within...
The ability to navigate “cocktail-party” situations by focussing on sounds of interest over irrelevant, background sounds is often considered in terms of cortical mechanisms. However, subcortical circuits such as the pathway underlying the medial olivocochlear (MOC) reflex modulate the activity of the inner ear itself, supporting the extraction of salient features from auditory scene prior to any cortical processing. To understand the contribution of auditory subcortical nuclei and the cochlea in complex listening tasks, we...
Cyclobis(paraquat-p-phenylene) as a synthetic receptor for electron-rich aromatic compounds: electrochemical and spectroscopic studies of neurotransmitter bindingAnna R. Bernardo, J. Fraser Stoddart & Angel E. Kaifer
This experiment examined the effects of social presence and perceived location of a virtual environment on participants’ pain thresholds in a pre-registered, within-subjects experiment. First, we examined the effects of social interaction vs being alone in a virtual environment. Second, we compared a virtual environment representing a remote location to a replication of the lab environment. While the "location" of the virtual environment did affect social presence, such that participants reported greater social presence with...
A template-directed protocol, which capitalizes on donor–acceptor interactions, is employed to synthesize a semi-rigid cyclophane (ExBox4+) that adopts a box-like geometry and is comprised of π-electron-poor 1,4-phenylene-bridged (“extended”) bipyridinium units (ExBIPY2+). ExBox4+ functions as a high-affinity scavenger of an array of different polycyclic aromatic hydrocarbons (PAHs), ranging from two to seven fused rings, as a result of its large, accommodating cavity (approximately 3.5 Å in width and 11.2 Å in length when considering the van...
Seoul Medical Center1
Serimmune (United States)1
University of Massachusetts Amherst1
Seoul National University Bundang Hospital1
Noguchi Memorial Institute for Medical Research1
Chonnam National University Hospital1
Dongguk University Ilsan Hospital1