526 Works

Additional file 2 of Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination

Na Wang, Minghui Wang, Suren Jeevaratnam, Cassandra Rosenberg, Tadafumi C. Ikezu, Francis Shue, Sydney V. Doss, Alla Alnobani, Yuka A. Martens, Melissa Wren, Yan W. Asmann, Bin Zhang, Guojun Bu & Chia-Chen Liu
Additional file 2: Figure sup 2. Lack of effects of cuprizone-induceddemyelination on the blood-brainbarrier integrity among apoE-TR mice. (A) Brain samples ofapoE-TR mice from CPZ-treated group (n=16/genotype) were subjected toimmunofluorescence staining for CLDN5(a tight junction-associated protein) and Glut1 (vascular marker). Representative images of CLDN5 (Green) staining and Glut1 (Red)staining in the CC region of apoE-TR mice are shown. Scale bar, 50 µm. Values are mean ± SEM. One-way ANOVA.N.S. not significant.

ZIF-8 modified poly (m-phenylene isophthalamide) (PMIA) hybrid membrane for dye wastewater treatment

Kailu Yang, Xibo Liu, Xinya Wang, Tianxu Hao, Wei Zhang & Mingxing Chen
The separation of dye/salt through the separation membranes is a great significance for the treatment of dye wastewater. In this study, a novel PMIA hybrid membrane was fabricated via nonsolvent induce phase separation (NIPS) method, in which porous zinc imidazolate framework-8 (ZIF-8) was utilized as a filler. The effect of ZIF-8 content on the structure and performance of PMIA/ZIF-8 membrane was investigated. The results showed that the structure and performance of the PMIA/ZIF-8 membrane could...

Additional file 1 of Global prevalence of Ascaris infection in humans (2010–2021): a systematic review and meta-analysis

Celia Holland, Mahdi Sepidarkish, Gwendoline Deslyper, Ali Abdollahi, Soghra Valizadeh, Abolfazl Mollalo, Sanaz Mahjour, Sahar Ghodsian, Ali Ardekani, Hamed Behniafar, Robin B. Gasser & Ali Rostami
Additional file 1: Table S1. Main characteristics of the included studies.

Additional file 2 of Global prevalence of Ascaris infection in humans (2010–2021): a systematic review and meta-analysis

Celia Holland, Mahdi Sepidarkish, Gwendoline Deslyper, Ali Abdollahi, Soghra Valizadeh, Abolfazl Mollalo, Sanaz Mahjour, Sahar Ghodsian, Ali Ardekani, Hamed Behniafar, Robin B. Gasser & Ali Rostami
Additional file 2: Table S2. The main characteristics of studies that included intensity of Ascaris infection.

Additional file 2 of Global prevalence of Ascaris infection in humans (2010–2021): a systematic review and meta-analysis

Celia Holland, Mahdi Sepidarkish, Gwendoline Deslyper, Ali Abdollahi, Soghra Valizadeh, Abolfazl Mollalo, Sanaz Mahjour, Sahar Ghodsian, Ali Ardekani, Hamed Behniafar, Robin B. Gasser & Ali Rostami
Additional file 2: Table S2. The main characteristics of studies that included intensity of Ascaris infection.

Additional file 3 of Global prevalence of Ascaris infection in humans (2010–2021): a systematic review and meta-analysis

Celia Holland, Mahdi Sepidarkish, Gwendoline Deslyper, Ali Abdollahi, Soghra Valizadeh, Abolfazl Mollalo, Sanaz Mahjour, Sahar Ghodsian, Ali Ardekani, Hamed Behniafar, Robin B. Gasser & Ali Rostami
Additional file 3: Table S3. Prevalence estimates for Ascaris infection based on sub-groups according to different geographic and climate parameters, calculated using a random effects model. Table S4. Association between study variables and heterogeneity of Ascariasis prevalence estimates.

Additional file 5 of Global prevalence of Ascaris infection in humans (2010–2021): a systematic review and meta-analysis

Celia Holland, Mahdi Sepidarkish, Gwendoline Deslyper, Ali Abdollahi, Soghra Valizadeh, Abolfazl Mollalo, Sanaz Mahjour, Sahar Ghodsian, Ali Ardekani, Hamed Behniafar, Robin B. Gasser & Ali Rostami
Additional file 5: Checklist S1. PRISMA checklist.

Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination

Na Wang, Minghui Wang, Suren Jeevaratnam, Cassandra Rosenberg, Tadafumi C. Ikezu, Francis Shue, Sydney V. Doss, Alla Alnobani, Yuka A. Martens, Melissa Wren, Yan W. Asmann, Bin Zhang, Guojun Bu & Chia-Chen Liu
Abstract Background Abnormal lipid accumulation has been recognized as a key element of immune dysregulation in microglia whose dysfunction contributes to neurodegenerative diseases. Microglia play essential roles in the clearance of lipid-rich cellular debris upon myelin damage or demyelination, a common pathogenic event in neuronal disorders. Apolipoprotein E (apoE) plays a pivotal role in brain lipid homeostasis; however, the apoE isoform-dependent mechanisms regulating microglial response upon demyelination remain unclear. Methods To determine how apoE isoforms...

The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε

Jia Luo, Jiajia Zhang, Jinghua Ni, Sen Jiang, Nengwen Xia, Yiwen Guo, Qi Shao, Qi Cao, Wanglong Zheng, Nanhua Chen, Quan Zhang, Hongjun Chen, Qing Chen, Hongfei Zhu, François Meurens & Jianzhong Zhu
African swine fever virus (ASFV), a large and complex cytoplasmic double-stranded DNA virus, has developed multiple strategies to evade the antiviral innate immune responses. Cytosolic DNA arising from invading ASFV is mainly detected by the cyclic GMP-AMP synthase (cGAS) and then triggers a series of innate immune responses to prevent virus invasion. However, the immune escape mechanism of ASFV remains to be fully clarified. The pS273R of ASFV is a member of the SUMO-1-specific protease...

The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε

Jia Luo, Jiajia Zhang, Jinghua Ni, Sen Jiang, Nengwen Xia, Yiwen Guo, Qi Shao, Qi Cao, Wanglong Zheng, Nanhua Chen, Quan Zhang, Hongjun Chen, Qing Chen, Hongfei Zhu, François Meurens & Jianzhong Zhu
African swine fever virus (ASFV), a large and complex cytoplasmic double-stranded DNA virus, has developed multiple strategies to evade the antiviral innate immune responses. Cytosolic DNA arising from invading ASFV is mainly detected by the cyclic GMP-AMP synthase (cGAS) and then triggers a series of innate immune responses to prevent virus invasion. However, the immune escape mechanism of ASFV remains to be fully clarified. The pS273R of ASFV is a member of the SUMO-1-specific protease...

Molecular, cellular and neurological consequences of infection by the neglected human pathogen Nocardia

Xingzhao Ji, Lichao Han, Weiying Zhang, Lina Sun, Shuai Xu, Xiaotong Qiu, Shihong Fan & Zhenjun Li
Abstract Background Nocardia is a facultative intracellular pathogen that infects the lungs and brains of immunocompromised patients with consequences that can be fatal. The incidence of such infections is rising, immunocompetent individuals are also being infected, and there is a need to learn more about this neglected bacterial pathogen and the interaction with its human host. Results We have applied dual RNA-seq to assess the global transcriptome changes that occur simultaneously in Nocardia farcinica (N....

Additional file 3 of CircRNA has_circ_0017109 promotes lung tumor progression via activation of Wnt/β-catenin signaling due to modulating miR-671-5p/FZD4 axis

Bo Yang, Bin Zhang, Qi Qi & Changli Wang
Additional file 3: Fig. S3. qRT-PCR analysis of FZD2, FZD3, FZD4 and FZD7 in NSCLC cells and HBE cells. All data were normalized to the expression level in HBE cells. *, P < 0.05, **, P < 0.01***, P < 0.001.

Modeling pedestrian behaviors of boarding and alighting dynamics in urban railway stations

Yunchao Qu, Xiaoying Liu, Jianjun Wu & Yun Wei
Boarding and alighting process is the most complicated behaviour at urban railway stations, and significantly affects the service level and evacuation capacities of stations. This paper quantitatively discusses the individual and group behavioural characteristics of both boarding and alighting passengers. The time headways are extracted from surveillance videos. Based on the data analysis results, an improved cellular automata model is proposed to describe the microscopic dynamics of the boarding and alighting process. In this model,...

Supplemental Material - Functional Limitations and Physical Health in Community-Dwelling Medicare Advantage Beneficiaries: Variation by Race and Hispanic Subgroup

Jeff Luck, Diana Govier, Lan N. Ðoàn, Shyama Mahakalanda, Wei Zhang & Carolyn Mendez-Luck
Supplemental Material for Functional Limitations and Physical Health in Community-Dwelling Medicare Advantage Beneficiaries: Variation by Race and Hispanic Subgroup by Jeff Luck, Diana Govier, Lan N. Ðoàn, Shyama Mahakalanda, Wei Zhang, and Carolyn Mendez-Luck in Journal of Aging and Health

Comparative clinical outcome following individualized follitropin delta dosing in Chinese women undergoing ovarian stimulation for in vitro fertilization /intracytoplasmic sperm injection

Rui Yang, Yunshan Zhang, Xiaoyan Liang, Xueru Song, Zhaolian Wei, Jianqiao Liu, Yezhou Yang, Jichun Tan, Qingxue Zhang, Yingpu Sun, Wei Wang, Weiping Qian, Lei Jin, Shuyu Wang, Yang Xu, Jing Yang, Marie Goethberg, Bernadette Mannaerts, Wen Wu, Zugeng Zheng & Jie Qiao
Abstract Background To compare the efficacy and safety of follitropin delta in its individualized fixed-dose regimen with follitropin alfa in a conventional adjustable dosing regimen in Chinese women. Methods This was a subgroup analysis of the randomized, multi-center, assessor-blind, non-inferiority trial (GRAPE) including 759 Chinese women (aged 20–40 years) recruited in 16 reproductive medicine clinics in China. Women were randomized in a 1:1 ratio to be treated with either follitropin delta dose based on anti-Müllerian...

Additional file 1 of Comparative clinical outcome following individualized follitropin delta dosing in Chinese women undergoing ovarian stimulation for in vitro fertilization /intracytoplasmic sperm injection

Rui Yang, Yunshan Zhang, Xiaoyan Liang, Xueru Song, Zhaolian Wei, Jianqiao Liu, Yezhou Yang, Jichun Tan, Qingxue Zhang, Yingpu Sun, Wei Wang, Weiping Qian, Lei Jin, Shuyu Wang, Yang Xu, Jing Yang, Marie Goethberg, Bernadette Mannaerts, Wen Wu, Zugeng Zheng & Jie Qiao
Additional file 1: Additional Figure 1. Study design and study timeline. AE, adverse event; OHSS, ovarian hyperstimulation syndrome; GnRH, gonadotropin-releasing hormone

Additional file 3 of Emergency versus delayed hepatectomy following transarterial embolization in spontaneously ruptured hepatocellular carcinoma survivors: a systematic review and meta-analysis

Wei Zhang, Zhangkan Huang & Xu Che
Additional file 3: Supplemental file 3. Begg’s test and Egger's test for each outcome.

Additional file 1 of Gastric duplication cyst with ectopic pancreas in a teenager successfully resected by endoscopic submucosal dissection

Xiaodan Ye, Muqing Wang, Yuanyuan Wang, Daiying Lin & Xiaozhong Wang
Additional file 1: Fig S1. The cystic portion’s cyst wall was lined by epithelium of gastric and surrounded by smooth muscle (hematoxylin and eosin [H&E] stain, ×10).

Additional file 2 of Gastric duplication cyst with ectopic pancreas in a teenager successfully resected by endoscopic submucosal dissection

Xiaodan Ye, Muqing Wang, Yuanyuan Wang, Daiying Lin & Xiaozhong Wang
Additional file 2: Fig S2. The solid portion was pancreatic tissues composed of acini, ducts, and islets of Langerhans (hematoxylin and eosin [H&E] stain, ×10).

Appenidx S1 Data sources for compiling distribution data from Preserving the woody plant tree of life in China under future climate and land-cover changes

Shijia Peng, Ruocheng Hu, Santiago José Elías Velazco, Yuan Luo, Tong Lyu, Xiaoling Zhang, Jian Zhang & Zhiheng Wang
The tree of life (TOL) is severely threatened by climate and land-cover changes. Preserving the TOL is urgent, but has not been included in the post-2020 global biodiversity framework. Protected areas (PAs) are fundamental for biological conservation. However, we know little about the effectiveness of existing PAs in preserving the TOL of plants and how to prioritize PA expansion for better TOL preservation under future climate and land-cover changes. Here, using high-resolution distribution maps of...

Appenidx S4 Supplementary Tables from Preserving the woody plant tree of life in China under future climate and land-cover changes

Shijia Peng, Ruocheng Hu, Santiago José Elías Velazco, Yuan Luo, Tong Lyu, Xiaoling Zhang, Jian Zhang & Zhiheng Wang
The tree of life (TOL) is severely threatened by climate and land-cover changes. Preserving the TOL is urgent, but has not been included in the post-2020 global biodiversity framework. Protected areas (PAs) are fundamental for biological conservation. However, we know little about the effectiveness of existing PAs in preserving the TOL of plants and how to prioritize PA expansion for better TOL preservation under future climate and land-cover changes. Here, using high-resolution distribution maps of...

Additional file 1 of Fecal microbiota transplantation combined with ruxolitinib as a salvage treatment for intestinal steroid-refractory acute GVHD

Yin Liu, Ye Zhao, Jiaqian Qi, Xiao Ma, Xiaofei Qi, Depei Wu & Yang Xu
Additional file 1: Figure S1. Comparison of inflammatory cytokines and T cell subsets in the four selected patients. A Comparison of IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ, and IL-17A levels detected in peripheral blood between baseline and the following 4 weeks after the initiation of combined treatment in Patient 1 with no response. The level of cytokines showed no significant change at 3 weeks and extraordinarily increased at the last follow-up, ending with death. B...

Is there variation in utilization of preoperative tests among patients undergoing total hip and knee replacement in the US, and does it affect outcomes? A population-based analysis

Mohamed Mosaad Hasan, Raymond Kang, Jungwha Lee, Matthew D. Beal, Abdalrahman G. Ahmed, Yao Tian & Hassan M. K. Ghomrawi
Abstract Study objective To describe recent practice patterns of preoperative tests and to examine their association with 90-day all-cause readmissions and length of stay. Design Retrospective cohort study using the New York Statewide Planning and Research Cooperative System (SPARCS). Setting SPARCS from March 1, 2016, to July 1, 2017. Participants Adults undergoing Total Hip Replacement (THR) or Total Knee Replacement (TKR) had a preoperative screening outpatient visit within two months before their surgery. Interventions Electrocardiogram...

Additional file 1 of Transcriptional and biochemical analyses of Planomicrobium strain AX6 from Qinghai-Tibetan Plateau, China, reveal hydrogen peroxide scavenging potential

Ali Bahadur, Ting Li, Wasim Sajjad, Fahad Nasir, Muhammad Amir Zia, Minghui Wu, Gaosen Zhang, Guangxiu Liu, Tuo Chen & Wei Zhang
Additional file 1: Table S1. The ability of anti-oxidantstrains to remove various oxidants: differentconcentrations of hydrogen peroxide (0, 1.5, and 3 mM of H2O2).Planomicrobium-AX6 is an antioxidantstrain isolated from the Qaidam Basin; the model strain Escherichia coli was used as a negative control; Deinococcus radiodurans was used as apositive control. Table S2. Summary of the sequencing data of strain Planomicrobium-AX6. Table S3 Selected significantly differentially expressed genes (DEGs) for strainPlanomicrobium-AX6 when exposed for 4hr to...

Additional file 1 of Marijuana use and DNA methylation-based biological age in young adults

Drew R. Nannini, Yinan Zheng, Brian T. Joyce, Tao Gao, Lei Liu, David R. Jacobs, Pamela Schreiner, Chunyu Liu, Steve Horvath, Ake T. Lu, Kristine Yaffe, Stephen Sidney, Philip Greenland, Donald M. Lloyd-Jones & Lifang Hou
Additional file 1: Supplemental Table 1. Interaction and stratified analysis results for the association between marijuana use and GrimAge acceleration at examination years 15 and 20 by tobacco smoking status. Supplemental Table 2. Interaction and stratified analysis results for the association between marijuana use and GrimAge acceleration at examination years 15 and 20 by race. Supplemental Table 3. Interaction and stratified analysis results for the association between marijuana use and GrimAge acceleration at examination years...

Registration Year

  • 2022
    526

Resource Types

  • Text
    248
  • Collection
    120
  • Dataset
    107
  • Image
    44
  • Audiovisual
    2
  • Journal Article
    2
  • Other
    2
  • Data Paper
    1

Affiliations

  • Northwestern University
    526
  • Sun Yat-sen University
    259
  • First Affiliated Hospital of Soochow University
    243
  • Zhejiang University
    235
  • Sichuan University
    235
  • Nanjing Medical University
    233
  • Shanghai Jiao Tong University
    225
  • Wuhan University
    221
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    217
  • Huazhong University of Science and Technology
    215