Additional file 1: Supplemental Table 1. Interaction and stratified analysis results for the association between marijuana use and GrimAge acceleration at examination years 15 and 20 by tobacco smoking status. Supplemental Table 2. Interaction and stratified analysis results for the association between marijuana use and GrimAge acceleration at examination years 15 and 20 by race. Supplemental Table 3. Interaction and stratified analysis results for the association between marijuana use and GrimAge acceleration at examination years...

Abstract Background Marijuana is the third most commonly used drug in the USA and efforts to legalize it for medical and recreational use are growing. Despite the increase in use, marijuana’s effect on aging remains understudied and understanding the effects of marijuana on molecular aging may provide novel insights into the role of marijuana in the aging process. We therefore sought to investigate the association between cumulative and recent use of marijuana with epigenetic age...

Additional file 4: Supplementary Figure 4.

Additional file 6: Supplementary Figure 6.

Abstract Background The COVID-19 pandemic has been a catalyst for rapid uptake of virtual care through the use of virtual health resources (VHR). In the Department of Veterans Affairs (VA) Healthcare System, virtual care has been critical to maintaining healthcare access for patients during COVID-19. In the current study we describe primary care patient aligned care team (PACT) VHR use patterns within one VA medical center (i.e., hospital facility and five community-based outpatient clinics) pre-...

The Buqingshan Complex, the eastern part of the Muztagh–Buqingshan–Anemaqen ophiolitic mélange zone (MBAM), contains a series of oceanic rocks that represent the remnants of the Paleo-Tethys Ocean. Field investigations reveal that the mafic-ultramafic rocks consist mainly of serpentinite, diabase, massive basalt, and pillow basalt. The serpentinites show similar geochemical characteristics to abyssal peridotites, which is probably the residual part of the depleted upper mantle after 17–20% melt extraction. The mafic rocks have geochemical affinities similar...

The Buqingshan Complex, the eastern part of the Muztagh–Buqingshan–Anemaqen ophiolitic mélange zone (MBAM), contains a series of oceanic rocks that represent the remnants of the Paleo-Tethys Ocean. Field investigations reveal that the mafic-ultramafic rocks consist mainly of serpentinite, diabase, massive basalt, and pillow basalt. The serpentinites show similar geochemical characteristics to abyssal peridotites, which is probably the residual part of the depleted upper mantle after 17–20% melt extraction. The mafic rocks have geochemical affinities similar...

We fabricated an ultrasound activated ‘nanobomb’ as a noninvasive and targeted physical therapeutic strategy for sonodynamic therapy and priming cancer immunotherapy. This ‘nanobomb’ was rationally designed via the encapsulation of indocyanine green (ICG) and perfluoropentane (PFP) into cRGD peptide-functionalized nano-liposome. The resulting Lip-ICG-PFP-cRGD nanoparticle linked with cRGD peptide could actively targeted ID8 and TC-1 cells and elicits ROS-mediated apoptosis after triggered by low-intensity focused ultrasound (LIFU). Moreover, the phase change of PFP (from droplets to...

Stroke is an illness with high morbidity, disability and mortality that presents a major clinical challenge. Sanhua decoction (SHD) has been widely used to treat ischaemic stroke in the clinic. However, the potential mechanism of SHD remains unknown. To elucidate the multitarget mechanism of SHD in ischaemic stroke through network pharmacology and bioinformatics analyses. Network pharmacology and experimental validation approach was used to investigate the bioactive ingredients, critical targets and potential mechanisms of SHD against...

Stroke is an illness with high morbidity, disability and mortality that presents a major clinical challenge. Sanhua decoction (SHD) has been widely used to treat ischaemic stroke in the clinic. However, the potential mechanism of SHD remains unknown. To elucidate the multitarget mechanism of SHD in ischaemic stroke through network pharmacology and bioinformatics analyses. Network pharmacology and experimental validation approach was used to investigate the bioactive ingredients, critical targets and potential mechanisms of SHD against...

To investigate the mechanism through which hyperthermia promotes exosome secretion and drug sensitivity in adriamycin-resistant breast cancer. We first evaluated the effect of hyperthermia on adriamycin-resistant breast cancer viability and used transmission electron microscopy, nanoparticle tracking analysis, and a bicinchoninic acid kit to validate the effect of hyperthermia on exosome secretion. The effective targeting molecules and pathways changed by hyperthermia were explored by RNA microarray and verified in vitro. The adriamycin-resistant MCF-7/ADR cells co-incubated with...

Line width and line type analysis

Supplemental material, sj-pdf-1-vmj-10.1177_1358863X221143152 for Cigarette smoking and mitochondrial dysfunction in peripheral artery disease by Michelle Guo, Mary M McDermott, Sudarshan Dayanidhi, Christiaan Leeuwenburgh, Stephanie Wohlgemuth, Luigi Ferrucci, Charlotte A Peterson, Kate Kosmac, Lu Tian, Lihui Zhao, Robert Sufit, Karen Ho, Michael Criqui, Shujun Xu, Dongxue Zhang and Philip Greenland in Vascular Medicine

Additional file 3: Supplementary Table S3. Spearman's correlation of individual signature score with immune marker immunohistochemistry (IHC).

Additional file 4: Supplementary Figures S1–S3. Supplementary Figure 1. Immune profiling in Nurses’ Health Study. A–B. GeparSixto immune gene expression score by receptor subtype (A) and intrinsic subtype (B). C. CD8 immunohistochemistry (IHC) in epithelial versus stromal compartments, line indicates best fit. D. GeparSixto immune gene expression score versus CD8 IHC epithelial+stromal. E. Correlation of GeparSixto immune gene expression score with CD8A single gene expression. Supplementary Figure 2. A–B. Evaluation of only tumors defined as...

Abstract Background Breast tumor immune infiltration is clearly associated with improved treatment response and outcomes in breast cancer. However, modifiable patient factors associated with breast cancer immune infiltrates are poorly understood. The Nurses’ Health Study (NHS) offers a unique cohort to study immune gene expression in tumor and adjacent normal breast tissue, immune cell-specific immunohistochemistry (IHC), and patient exposures. We evaluated the association of body mass index (BMI) change since age 18, physical activity, and...

We, the Editors and Publisher of the journalArchives of Physiology and Biochemistry, have retracted the following article: Wei Zhang, Jun Ma, Shan Wang, Tao Huang & Min Xia (2020) Tranilast attenuates neuropathic pain during type-2 diabetes by inhibiting hypoxia-induced pro-inflammatory cytokines in Zucker diabetic fatty rat model, Archives of Physiology and Biochemistry, DOI: 10.1080/13813455.2020.1854309 Since publication, the authors informed the Publisher and Editor that the authors had not received ethics approval from the Institutional Animal...

Additional file 2: SupplementaryFigure 2. The network map of top 10 institutions (A) and the top 10 cited networkmap of institutions in this field (B).

Additional file 5: Supplementary Table 3. The top 10 Keywordsrelated to this field.

Supplemental material, sj-docx-1-shr-10.1177_20542704221127178 for Quality of the Indian clinical practice guidelines for the management of cardiovascular conditions by Rupasvi Dhurjati, Vidya Sagar, Raju Kanukula, Nusrath Rehana, Padinhare P Mohanan, Mark D. Huffman, Soumyadeep Bhaumik and Abdul Salam in JRSM Open

To assess the quality of Indian clinical practice guidelines (CPG)s for the management of cardiovascular conditions, MEDLINE, Embase, Google Scholar and websites of relevant medical associations and government organisations were searched, from inception until August 2020, to identify Indian CPGs for the management of cardiovascular disease (CVD) conditions, produced in or between 2010 and 2019. Excluded were CPGs that were not specific to India, focused on alternative systems of medicine, of non-CVD conditions (even if...

SARS-CoV-2 variants continue to emerge facing established herd immunity. L452R, previously featured in the Delta variant, quickly emerged in Omicron subvariants, including BA.4/BA.5, implying a continued selection pressure on this residue. The underlying links between spike mutations and their selective pressures remain incompletely understood. Here, by analyzing 221 structurally characterized antibodies, we found that IGHV1-69-encoded antibodies preferentially contact L452 using germline-encoded hydrophobic residues at the tip of HCDR2 loop. Whereas somatic hypermutations or VDJ rearrangements...

Additional file 1: Table S1. Mean (SD) for unadjusted muscle volume for each group (chronic idiopathic neck pain and asymptomatic) calculated per MRI slice for each muscle at each spinal level, with mean difference (95% CI) between groups. Table S2. Mean (SD) for unadjusted relative muscle volume for each group (chronic idiopathic neck pain and asymptomatic) calculated per MRI slice for each muscle at each spinal level, with mean difference (95% CI) between groups. Table...

Additional file 1: Table S1. Mean (SD) for unadjusted muscle volume for each group (chronic idiopathic neck pain and asymptomatic) calculated per MRI slice for each muscle at each spinal level, with mean difference (95% CI) between groups. Table S2. Mean (SD) for unadjusted relative muscle volume for each group (chronic idiopathic neck pain and asymptomatic) calculated per MRI slice for each muscle at each spinal level, with mean difference (95% CI) between groups. Table...

Abstract Muscle size and composition (muscle volume and muscle fat infiltrate [MFI]) may provide insight into possible mechanisms underpinning chronic idiopathic neck pain, a common condition with no definitive underlying pathology. In individuals with chronic idiopathic neck pain > 3 months and age- and sex-matched asymptomatic controls, muscle volumes of levator scapulae, multifidus including semispinalis cervicis (MFSS), semispinalis capitis, splenius capitis including splenius cervicis (SCSC), sternocleidomastoid and longus colli from C3 through T1 were quantified...